Characterization of one anastomosis gastric ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Title :
Characterization of one anastomosis gastric bypass and impact of biliary and common limbs on bile acid and postprandial glucose metabolism in a minipig model.
Author(s) :
Marciniak, C. [Auteur]
Chávez-Talavera, O. [Auteur]
Caiazzo, Robert [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Hubert, Thomas [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Zubiaga, L. [Auteur]
Baud, G. [Auteur]
Quenon, A. [Auteur]
Descat, A. [Auteur]
Vallez, E. [Auteur]
Goossens, Jean-Francois [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Kouach, M. [Auteur]
Vangelder, V. [Auteur]
Gobert, M. [Auteur]
Daoudi, Mehdi [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Derudas, B. [Auteur]
Pigny, Pascal [Auteur]
Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Klein, A. [Auteur]
Gmyr, Valery [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Raverdy, V. [Auteur]
Lestavel, Sophie [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Laferrère, B. [Auteur]
Staels, B. [Auteur]
Tailleux, A. [Auteur]
Pattou, F. [Auteur]
Chávez-Talavera, O. [Auteur]
Caiazzo, Robert [Auteur]

Recherche translationnelle sur le diabète - U 1190 [RTD]
Hubert, Thomas [Auteur]

Recherche translationnelle sur le diabète - U 1190 [RTD]
Zubiaga, L. [Auteur]
Baud, G. [Auteur]
Quenon, A. [Auteur]
Descat, A. [Auteur]
Vallez, E. [Auteur]
Goossens, Jean-Francois [Auteur]

Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Kouach, M. [Auteur]
Vangelder, V. [Auteur]
Gobert, M. [Auteur]
Daoudi, Mehdi [Auteur]

Recherche translationnelle sur le diabète - U 1190 [RTD]
Derudas, B. [Auteur]
Pigny, Pascal [Auteur]

Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Klein, A. [Auteur]
Gmyr, Valery [Auteur]

Recherche translationnelle sur le diabète - U 1190 [RTD]
Raverdy, V. [Auteur]
Lestavel, Sophie [Auteur]

Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Laferrère, B. [Auteur]
Staels, B. [Auteur]
Tailleux, A. [Auteur]
Pattou, F. [Auteur]
Journal title :
American Journal of Physiology - Endocrinology and Metabolism
Pages :
E772-E783
Publication date :
2021-01-26
English keyword(s) :
bariatric
bariatric surgery
bile acids
biliary limb
bypass
common limb
one anastomosis gastric bypass
bariatric surgery
bile acids
biliary limb
bypass
common limb
one anastomosis gastric bypass
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The alimentary limb has been proposed to be a key driver of the weight-loss-independent metabolic improvements that occur upon bariatric surgery. However, the one anastomosis gastric bypass (OAGB) procedure, consisting of ...
Show more >The alimentary limb has been proposed to be a key driver of the weight-loss-independent metabolic improvements that occur upon bariatric surgery. However, the one anastomosis gastric bypass (OAGB) procedure, consisting of one long biliary limb and a short common limb, induces similar beneficial metabolic effects compared to Roux-en-Y Gastric Bypass (RYGB) in humans, despite the lack of an alimentary limb. The aim of this study was to assess the role of the length of biliary and common limbs in the weight loss and metabolic effects that occur upon OAGB. OAGB and sham surgery, with or without modifications of the length of either the biliary limb or the common limb, were performed in Gottingen minipigs. Weight loss, metabolic changes, and the effects on plasma and intestinal bile acids (BAs) were assessed 15 days after surgery. OAGB significantly decreased body weight, improved glucose homeostasis, increased postprandial GLP-1 and fasting plasma BAs, and qualitatively changed the intestinal BA species composition. Resection of the biliary limb prevented the body weight loss effects of OAGB and attenuated the postprandial GLP-1 increase. Improvements in glucose homeostasis along with changes in plasma and intestinal BAs occurred after OAGB regardless of the biliary limb length. Resection of only the common limb reproduced the glucose homeostasis effects and the changes in intestinal BAs. Our results suggest that the changes in glucose metabolism and BAs after OAGB are mainly mediated by the length of the common limb, whereas the length of the biliary limb contributes to body weight loss.NEW & NOTEWORTHY Common limb mediates postprandial glucose metabolism change after gastric bypass whereas biliary limb contributes to weight loss.Show less >
Show more >The alimentary limb has been proposed to be a key driver of the weight-loss-independent metabolic improvements that occur upon bariatric surgery. However, the one anastomosis gastric bypass (OAGB) procedure, consisting of one long biliary limb and a short common limb, induces similar beneficial metabolic effects compared to Roux-en-Y Gastric Bypass (RYGB) in humans, despite the lack of an alimentary limb. The aim of this study was to assess the role of the length of biliary and common limbs in the weight loss and metabolic effects that occur upon OAGB. OAGB and sham surgery, with or without modifications of the length of either the biliary limb or the common limb, were performed in Gottingen minipigs. Weight loss, metabolic changes, and the effects on plasma and intestinal bile acids (BAs) were assessed 15 days after surgery. OAGB significantly decreased body weight, improved glucose homeostasis, increased postprandial GLP-1 and fasting plasma BAs, and qualitatively changed the intestinal BA species composition. Resection of the biliary limb prevented the body weight loss effects of OAGB and attenuated the postprandial GLP-1 increase. Improvements in glucose homeostasis along with changes in plasma and intestinal BAs occurred after OAGB regardless of the biliary limb length. Resection of only the common limb reproduced the glucose homeostasis effects and the changes in intestinal BAs. Our results suggest that the changes in glucose metabolism and BAs after OAGB are mainly mediated by the length of the common limb, whereas the length of the biliary limb contributes to body weight loss.NEW & NOTEWORTHY Common limb mediates postprandial glucose metabolism change after gastric bypass whereas biliary limb contributes to weight loss.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
ANR Project :
Source :