Antifungal Properties of Hydrazine-Based ...
Type de document :
Article dans une revue scientifique: Article original
URL permanente :
Titre :
Antifungal Properties of Hydrazine-Based Compounds against Candida albicans
Auteur(s) :
Camaioni, Louis [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Service de Parasitologie-Mycologie [CHRU LIlle]
Faculté de Médecine Henri Warembourg - Université de Lille
Lambert, Dylan [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Service de Parasitologie-Mycologie [CHRU LIlle]
Faculté de Médecine Henri Warembourg - Université de Lille
Sendid, Boualem [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Service de Parasitologie-Mycologie [CHRU LIlle]
Faculté de Médecine Henri Warembourg - Université de Lille
Billamboz, Muriel [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
JUNIA [JUNIA]
Jawhara, Samir [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Service de Parasitologie-Mycologie [CHRU LIlle]
Faculté de Médecine Henri Warembourg - Université de Lille
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Service de Parasitologie-Mycologie [CHRU LIlle]
Faculté de Médecine Henri Warembourg - Université de Lille
Lambert, Dylan [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Service de Parasitologie-Mycologie [CHRU LIlle]
Faculté de Médecine Henri Warembourg - Université de Lille
Sendid, Boualem [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Service de Parasitologie-Mycologie [CHRU LIlle]
Faculté de Médecine Henri Warembourg - Université de Lille
Billamboz, Muriel [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
JUNIA [JUNIA]
Jawhara, Samir [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Service de Parasitologie-Mycologie [CHRU LIlle]
Faculté de Médecine Henri Warembourg - Université de Lille
Titre de la revue :
Antibiotics
Numéro :
12
Pagination :
1043
Éditeur :
MDPI
Date de publication :
2023-06-12
ISSN :
2079-6382
Mot(s)-clé(s) en anglais :
Candida albicans
hydrazine
biofilm
fungal resistance
Caenorhabditis elegans infection model
hydrazine
biofilm
fungal resistance
Caenorhabditis elegans infection model
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
Candida albicans, an opportunistic yeast, is the most common cause of fungal infection. In the past decade, there has been an increase in C. albicans resistance to existing antifungal drugs, which has necessitated the ...
Lire la suite >Candida albicans, an opportunistic yeast, is the most common cause of fungal infection. In the past decade, there has been an increase in C. albicans resistance to existing antifungal drugs, which has necessitated the development of new antifungal agents. In the present study, screening 60 compounds from the JUNIA chemical library enabled us to explore an additional 11 hybrid compounds that contain pyrrolidinone rings and hydrazine moieties for their potential antifungal activities. This chemical series was identified with fair to excellent antifungal activities. Among this series, three molecules (Hyd.H, Hyd.OCH3, and Hyd.Cl) significantly reduced C. albicans viability, with rapid fungicidal activity. In addition, these three compounds exhibited significant antifungal activity against clinically isolated fluconazole- or caspofungin-resistant C. albicans strains. Hyd.H, Hyd.OCH3, and Hyd.Cl did not show any cytotoxicity against human cancer cell lines up to a concentration of 50 µg/mL and decreased Candida biofilm formation, with a significant reduction of 60% biofilm formation with Hyd.OCH3. In an infection model of Caenorhabditis elegans with C. albicans, hydrazine-based compounds significantly reduced nematode mortality. Overall, fungicidal activity was observed for Hyd.H, Hyd.OCH3, and Hyd.Cl against C. albicans, and these compounds protected C. elegans from C. albicans infection.Lire moins >
Lire la suite >Candida albicans, an opportunistic yeast, is the most common cause of fungal infection. In the past decade, there has been an increase in C. albicans resistance to existing antifungal drugs, which has necessitated the development of new antifungal agents. In the present study, screening 60 compounds from the JUNIA chemical library enabled us to explore an additional 11 hybrid compounds that contain pyrrolidinone rings and hydrazine moieties for their potential antifungal activities. This chemical series was identified with fair to excellent antifungal activities. Among this series, three molecules (Hyd.H, Hyd.OCH3, and Hyd.Cl) significantly reduced C. albicans viability, with rapid fungicidal activity. In addition, these three compounds exhibited significant antifungal activity against clinically isolated fluconazole- or caspofungin-resistant C. albicans strains. Hyd.H, Hyd.OCH3, and Hyd.Cl did not show any cytotoxicity against human cancer cell lines up to a concentration of 50 µg/mL and decreased Candida biofilm formation, with a significant reduction of 60% biofilm formation with Hyd.OCH3. In an infection model of Caenorhabditis elegans with C. albicans, hydrazine-based compounds significantly reduced nematode mortality. Overall, fungicidal activity was observed for Hyd.H, Hyd.OCH3, and Hyd.Cl against C. albicans, and these compounds protected C. elegans from C. albicans infection.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Projet ANR :
Établissement(s) :
Université de Lille
CNRS
CNRS
Collections :
Équipe(s) de recherche :
Glycobiology in fungal Pathogenesis and Clinical Applications
Date de dépôt :
2023-09-27T08:51:41Z
2023-09-28T11:30:43Z
2023-09-28T11:31:24Z
2023-09-28T11:30:43Z
2023-09-28T11:31:24Z
Fichiers
- P23.31 antibiotics-12-01043.pdf
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