Antifungal Properties of Hydrazine-Based ...
Document type :
Article dans une revue scientifique: Article original
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Title :
Antifungal Properties of Hydrazine-Based Compounds against Candida albicans
Author(s) :
Camaioni, Louis [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Service de Parasitologie-Mycologie [CHRU LIlle]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Lambert, Dylan [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Service de Parasitologie-Mycologie [CHRU LIlle]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Sendid, Boualem [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Service de Parasitologie-Mycologie [CHRU LIlle]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Billamboz, Muriel [Auteur]
JUNIA [JUNIA]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Jawhara, Samir [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Service de Parasitologie-Mycologie [CHRU LIlle]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Faculté de Médecine Henri Warembourg - Université de Lille
Service de Parasitologie-Mycologie [CHRU LIlle]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Lambert, Dylan [Auteur]
Faculté de Médecine Henri Warembourg - Université de Lille
Service de Parasitologie-Mycologie [CHRU LIlle]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Sendid, Boualem [Auteur]

Faculté de Médecine Henri Warembourg - Université de Lille
Service de Parasitologie-Mycologie [CHRU LIlle]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Billamboz, Muriel [Auteur]

JUNIA [JUNIA]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Jawhara, Samir [Auteur]

Faculté de Médecine Henri Warembourg - Université de Lille
Service de Parasitologie-Mycologie [CHRU LIlle]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Journal title :
Antibiotics
Volume number :
12
Pages :
1043
Publisher :
MDPI
Publication date :
2023-06-12
ISSN :
2079-6382
English keyword(s) :
Candida albicans
hydrazine
biofilm
fungal resistance
Caenorhabditis elegans infection model
hydrazine
biofilm
fungal resistance
Caenorhabditis elegans infection model
HAL domain(s) :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
English abstract : [en]
Candida albicans, an opportunistic yeast, is the most common cause of fungal infection. In the past decade, there has been an increase in C. albicans resistance to existing antifungal drugs, which has necessitated the ...
Show more >Candida albicans, an opportunistic yeast, is the most common cause of fungal infection. In the past decade, there has been an increase in C. albicans resistance to existing antifungal drugs, which has necessitated the development of new antifungal agents. In the present study, screening 60 compounds from the JUNIA chemical library enabled us to explore an additional 11 hybrid compounds that contain pyrrolidinone rings and hydrazine moieties for their potential antifungal activities. This chemical series was identified with fair to excellent antifungal activities. Among this series, three molecules (Hyd.H, Hyd.OCH3, and Hyd.Cl) significantly reduced C. albicans viability, with rapid fungicidal activity. In addition, these three compounds exhibited significant antifungal activity against clinically isolated fluconazole- or caspofungin-resistant C. albicans strains. Hyd.H, Hyd.OCH3, and Hyd.Cl did not show any cytotoxicity against human cancer cell lines up to a concentration of 50 µg/mL and decreased Candida biofilm formation, with a significant reduction of 60% biofilm formation with Hyd.OCH3. In an infection model of Caenorhabditis elegans with C. albicans, hydrazine-based compounds significantly reduced nematode mortality. Overall, fungicidal activity was observed for Hyd.H, Hyd.OCH3, and Hyd.Cl against C. albicans, and these compounds protected C. elegans from C. albicans infection.Show less >
Show more >Candida albicans, an opportunistic yeast, is the most common cause of fungal infection. In the past decade, there has been an increase in C. albicans resistance to existing antifungal drugs, which has necessitated the development of new antifungal agents. In the present study, screening 60 compounds from the JUNIA chemical library enabled us to explore an additional 11 hybrid compounds that contain pyrrolidinone rings and hydrazine moieties for their potential antifungal activities. This chemical series was identified with fair to excellent antifungal activities. Among this series, three molecules (Hyd.H, Hyd.OCH3, and Hyd.Cl) significantly reduced C. albicans viability, with rapid fungicidal activity. In addition, these three compounds exhibited significant antifungal activity against clinically isolated fluconazole- or caspofungin-resistant C. albicans strains. Hyd.H, Hyd.OCH3, and Hyd.Cl did not show any cytotoxicity against human cancer cell lines up to a concentration of 50 µg/mL and decreased Candida biofilm formation, with a significant reduction of 60% biofilm formation with Hyd.OCH3. In an infection model of Caenorhabditis elegans with C. albicans, hydrazine-based compounds significantly reduced nematode mortality. Overall, fungicidal activity was observed for Hyd.H, Hyd.OCH3, and Hyd.Cl against C. albicans, and these compounds protected C. elegans from C. albicans infection.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
ANR Project :
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Collections :
Research team(s) :
Glycobiology in fungal Pathogenesis and Clinical Applications
Submission date :
2023-09-27T08:51:41Z
2023-09-28T11:30:43Z
2023-09-28T11:31:24Z
2023-09-28T11:30:43Z
2023-09-28T11:31:24Z
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