Title :

Persistent Asthma Is Associated With Carotid Plaque in MESA.

Author(s) :

Tattersall, Matthew C [Auteur]
University of Wisconsin School of Medicine and Public Health
Dasiewicz, Alison S [Auteur]
The Hospital for sick children [Toronto] [SickKids]
McClelland, Robyn L [Auteur]
University of Washington [Seattle]
Jarjour, Nizar N [Auteur]
Johns Hopkins University School of Medicine [Baltimore]
Korcarz, Claudia E [Auteur]
University of Wisconsin School of Medicine and Public Health
Mitchell, Carol C [Auteur]
University of Wisconsin School of Medicine and Public Health
Esnault, Stephane [Auteur]
University of Wisconsin-Madison
Szklo, Moyses [Auteur]
Johns Hopkins University School of Medicine [Baltimore]
Stein, James H [Auteur]
University of Wisconsin School of Medicine and Public Health

Journal title :

Journal of the American Heart Association

Abbreviated title :

J Am Heart Assoc

Volume number :

11

Pages :

e026644

Publisher :

Wiley-Blackwell

Publication date :

2022-12-06

ISSN :

2047-9980

English keyword(s) :

Female
Humans
Male
Middle Aged
Interleukin-6
Asthma
Plaque, Atherosclerotic
Carotid Artery Diseases
Black or African American
Hispanic or Latino
East Asian People
Aged
Risk
asthma
carotid plaque
inflammation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Asthma and atherosclerotic cardiovascular disease share an underlying inflammatory pathophysiology. We hypothesized that persistent asthma is associated with carotid plaque burden, a strong predictor of ...
Show more >Background Asthma and atherosclerotic cardiovascular disease share an underlying inflammatory pathophysiology. We hypothesized that persistent asthma is associated with carotid plaque burden, a strong predictor of atherosclerotic cardiovascular disease events. Methods and Results The MESA (Multi-Ethnic Study of Atherosclerosis) enrolled adults free of known atherosclerotic cardiovascular disease at baseline. Subtype of asthma was determined at examination 1. Persistent asthma was defined as asthma requiring use of controller medications, and intermittent asthma was defined as asthma without controller medications. B-mode carotid ultrasound was performed to detect carotid plaques (total plaque score [TPS], range 0-12). Multivariable regression modeling with robust variances evaluated the association of asthma subtype and carotid plaque burden. The 5029 participants were a mean (SD) age of 61.6 (10.0) years (53% were women, 26% were Black individuals, 23% were Hispanic individuals, and 12% were Chinese individuals). Carotid plaque was present in 50.5% of participants without asthma (TPS, 1.29 [1.80]), 49.5% of participants with intermittent asthma (TPS, 1.25 [1.76]), and 67% of participants with persistent asthma (TPS, 2.08 [2.35]) (≤0.003). Participants with persistent asthma had higher interleukin-6 (1.89 [1.61] pg/mL) than participants without asthma (1.52 [1.21] pg/mL; =0.02). In fully adjusted models, persistent asthma was associated with carotid plaque presence (odds ratio, 1.83 [95% confidence interval, 1.21-2.76]; <0.001) and TPS (β=0.66; <0.01), without attenuation after adjustment for baseline interleukin-6 (=0.02) or CRP (C-reactive protein) (=0.01). Conclusions Participants with persistent asthma had higher carotid plaque burden and higher levels of inflammatory biomarkers, compared with participants without asthma. Adjustment for baseline inflammatory biomarkers did not attenuate the association between carotid plaque and asthma subtype, highlighting the increased atherosclerotic cardiovascular disease risk among those with persistent asthma may be multifactorial.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2023-10-18T11:30:56Z
2023-11-08T10:19:30Z