Therapeutic Potential of Chlorhexidine-Loaded ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Therapeutic Potential of Chlorhexidine-Loaded Calcium Hydroxide-Based Intracanal Medications in Endo-Periodontal Lesions: An Ex Vivo and In Vitro Study.
Auteur(s) :
Sy, Kadiatou [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Chevalier, C. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Maton, Mickael [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Mokbel, I. [Auteur]
Laboratoire des Multimatériaux et Interfaces [LMI]
Mahieux, Séverine [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Houcke, Isabelle [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Neut, Christel [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Grosgogeat, Brigitte [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Deveaux, Etienne [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Gritsch, K. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Agossa, Kevimy [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Chevalier, C. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Maton, Mickael [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Mokbel, I. [Auteur]
Laboratoire des Multimatériaux et Interfaces [LMI]
Mahieux, Séverine [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Houcke, Isabelle [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Neut, Christel [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Grosgogeat, Brigitte [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Deveaux, Etienne [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Gritsch, K. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Agossa, Kevimy [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Titre de la revue :
Antibiotics
Nom court de la revue :
Antibiotics
Numéro :
12
Pagination :
1416
Éditeur :
MDPI
Date de publication :
2023-09-07
ISSN :
2079-6382
Mot(s)-clé(s) en anglais :
endo-periodontal lesions
intracanal medication
ion release
local drug delivery
periodontal cells
intracanal medication
ion release
local drug delivery
periodontal cells
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Endo-periodontal lesions are challenging clinical situations where both the supporting tissues and the root canal of the same tooth are infected. In the present study, chlorhexidine (CHX)-loaded calcium hydroxide (CH) ...
Lire la suite >Endo-periodontal lesions are challenging clinical situations where both the supporting tissues and the root canal of the same tooth are infected. In the present study, chlorhexidine (CHX)-loaded calcium hydroxide (CH) pastes were used as intracanal medications (ICMs). They were prepared and tested on pathogens found in both the root canal and the periodontal pocket. Exposure to 0.5% and 1% CHX-loaded ICMs decreased the growth of Porphyromonas gingivalis and was effective in eradicating or inhibiting an Enterococcus faecalis biofilm. CH was injected into the root canal of extracted human teeth immersed in deionized water. CHX-loaded ICMs resulted in the transradicular diffusion of active components outside the tooth through the apex and the lateral dentinal tubules, as shown by the release of CHX (from 3.99 µg/mL to 51.28 µg/mL) and changes in pH (from 6.63 to 8.18) and calcium concentrations (from 2.42 ppm to 14.67 ppm) after 7 days. The 0.5% CHX-loaded ICM was non-toxic and reduced the release of IL-6 by periodontal cells stimulated by P. gingivalis lipopolysaccharides. Results indicate that the root canal may serve as a reservoir for periodontal drug delivery and that CHX-based ICMs can be an adjuvant for the control of infections and inflammation in endo-periodontal lesions.Lire moins >
Lire la suite >Endo-periodontal lesions are challenging clinical situations where both the supporting tissues and the root canal of the same tooth are infected. In the present study, chlorhexidine (CHX)-loaded calcium hydroxide (CH) pastes were used as intracanal medications (ICMs). They were prepared and tested on pathogens found in both the root canal and the periodontal pocket. Exposure to 0.5% and 1% CHX-loaded ICMs decreased the growth of Porphyromonas gingivalis and was effective in eradicating or inhibiting an Enterococcus faecalis biofilm. CH was injected into the root canal of extracted human teeth immersed in deionized water. CHX-loaded ICMs resulted in the transradicular diffusion of active components outside the tooth through the apex and the lateral dentinal tubules, as shown by the release of CHX (from 3.99 µg/mL to 51.28 µg/mL) and changes in pH (from 6.63 to 8.18) and calcium concentrations (from 2.42 ppm to 14.67 ppm) after 7 days. The 0.5% CHX-loaded ICM was non-toxic and reduced the release of IL-6 by periodontal cells stimulated by P. gingivalis lipopolysaccharides. Results indicate that the root canal may serve as a reservoir for periodontal drug delivery and that CHX-based ICMs can be an adjuvant for the control of infections and inflammation in endo-periodontal lesions.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Date de dépôt :
2023-10-20T04:53:01Z
2023-10-23T07:32:08Z
2023-10-23T07:32:08Z
Fichiers
- antibiotics-12-014161.pdf
- Version éditeur
- Accès libre
- Accéder au document