Titre :

In the case of extensively putrefied bodies, the analysis of entomological samples may support and complement the toxicological results obtained with other alternative matrices.

Auteur(s) :

Aly, S. M. [Auteur]
Gish, Alexandr [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Toxicologie et Génopathies [CHRU Lille]
Hakim, Florian [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Toxicologie et Génopathies [CHRU Lille]
Guelmi, D. [Auteur]
Mesli, Vadim [Auteur]
Unité de Taphonomie Médico-Légale (UTML) - ULR 7367
Hedouin, Valery [Auteur]
Unité de Taphonomie Médico-Légale & d’Anatomie (UTMLA) - ULR 7367
Allorge, Delphine [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Gaulier, Jean-Michel [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Titre de la revue :

Legal Medicine

Nom court de la revue :

Leg Med (Tokyo)

Numéro :

63

Pagination :

102261

Date de publication :

2023-04-24

ISSN :

1873-4162

Mot(s)-clé(s) en anglais :

Forensic
Toxicology
Putrefaction
Pupae
Insect

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Entomotoxicological analysis is not part of routine toxicological analysis. This work aims to present two cases to illustrate the potential of entomological samples as complementary matrices to identify substances in cases ...
Lire la suite >Entomotoxicological analysis is not part of routine toxicological analysis. This work aims to present two cases to illustrate the potential of entomological samples as complementary matrices to identify substances in cases of advanced putrefaction. (Case#1) A woman was exhumed after 14 months to ascertain the exact cause of death. She died after six weeks of hospitalization because of intestinal ischemia followed by multiorgan failure. (Case#2) The corpse of a woman, known to have a psychiatric disorder, was discovered in her apartment. The state of decomposition of the body was consistent with a post-mortem period of several weeks (approximately 6 weeks). Toxicological investigations were performed in the biological and entomological samples of case#1 (hair, adipocere, brain, and pupae) and of case#2 (hair, bone, flies, and pupae) using liquid chromatography with high-resolution mass spectrometry and tandem mass spectrometry detection methods. In case#1, several drugs and metabolites were detected. In particular, the pupae analyses allowed the objectification of morphine administration, whereas morphine was only found in adipocere, but not in hair nor in brain. In case#2, the pupae analyses allowed the detection of three metabolites of quetiapine, and the flies analyses allowed the detection of valpromide, which was only detected in hair. In conclusion, the pupae and flies analyses in these two cases complemented the results obtained in the other alternative biological samples, which may guide hypotheses about the possible causes of death. Nevertheless, additional data and case reports would be of benefit to assess the value of entomotoxicology in routine forensic investigations.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Unité de Taphonomie Médico-Légale & d’Anatomie (UTMLA) - ULR 7367

Date de dépôt :

2023-10-20T05:49:43Z
2024-02-29T14:29:42Z