Title :

Plasma thymic stromal lymphopoietin (TSLP) in adults with non-severe asthma: the EGEA study.

Author(s) :

Ibrahim, Bakari [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Achour, Djamal [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Zerimech, Farid [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
De Nadai, Patricia [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Siroux, Valérie [Auteur]
Tsicopoulos, Anne [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Matran, Regis [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Granger, Vanessa [Auteur]
Nadif, Rachel [Auteur]

Journal title :

Thorax

Abbreviated title :

Thorax

Volume number :

78

Pages :

207-210

Publisher :

BMJ Publishing Group

Publication date :

2022-12-14

ISSN :

0040-6376

English keyword(s) :

Asthma
Asthma Epidemiology
Cytokine Biology

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Thymic stromal lymphopoietin (TSLP), a cytokine involved in severe asthma treatment, was never studied in non-severe asthma. Among 969 adults from a large epidemiological study, cross-sectional analyses showed that ...
Show more >Thymic stromal lymphopoietin (TSLP), a cytokine involved in severe asthma treatment, was never studied in non-severe asthma. Among 969 adults from a large epidemiological study, cross-sectional analyses showed that plasma TSLP levels were associated with increased age and BMI, male sex, smoking and high TSLP levels (one IQR increase) with current asthma and poor lung function. High TSLP levels were also associated with persistence of asthma attacks (aOR=2.14 (95% CI 1.23 to 3.72)) and dyspnoea (aOR=2.71 (95% CI 1.39 to 5.28)) 10 years later. Our results suggest that TSLP could be a cytokine of interest in non-severe asthma, and its determinants of circulating levels could be considered in asthma management.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Research team(s) :

Immunité Pulmonaire

Submission date :

2023-10-20T05:56:06Z
2024-02-26T16:28:59Z
2024-02-26T16:31:50Z