Mild pulmonary hemodynamic alterations in ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Mild pulmonary hemodynamic alterations in patients with systemic sclerosis: relevance of the new 2022 ESC/ERS definition of pulmonary hypertension and impact on mortality.
Auteur(s) :
Puigrenier, S. [Auteur]
Giovannelli, Jonathan [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lamblin, Nicolas [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
De Groote, Pascal [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Fertin, M. [Auteur]
Bervar, J. F. [Auteur]
Lamer, Antoine [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Edme, Jean-Louis [Auteur]
IMPact de l’Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Balquet, M. H. [Auteur]
Sobanski, Vincent [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Sanges, Sébastien [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Giovannelli, Jonathan [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lamblin, Nicolas [Auteur]

Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
De Groote, Pascal [Auteur]

Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Fertin, M. [Auteur]
Bervar, J. F. [Auteur]
Lamer, Antoine [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Edme, Jean-Louis [Auteur]

IMPact de l’Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Balquet, M. H. [Auteur]
Sobanski, Vincent [Auteur]

Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Launay, David [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Hachulla, Eric [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Sanges, Sébastien [Auteur]

Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Titre de la revue :
Respiratory Research
Nom court de la revue :
Respir Res
Numéro :
23
Pagination :
284
Date de publication :
2022-10-17
ISSN :
1465-993X
Mot(s)-clé(s) en anglais :
Systemic sclerosis
Pulmonary hypertension
Pulmonary arterial hypertension
Pulmonary vascular resistance
Diagnostic criteria
Mortality
Pulmonary hypertension
Pulmonary arterial hypertension
Pulmonary vascular resistance
Diagnostic criteria
Mortality
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Background and objective
The definition of pre-capillary pulmonary hypertension (PH) has been modified, with lowering of the mean pulmonary arterial pressure (mPAP) threshold from 25 to 20 mmHg and addition of a mandatory ...
Lire la suite >Background and objective The definition of pre-capillary pulmonary hypertension (PH) has been modified, with lowering of the mean pulmonary arterial pressure (mPAP) threshold from 25 to 20 mmHg and addition of a mandatory criterion of pulmonary vascular resistance (PVR) ≥ 2 Wood units (WU). Our objectives were: 1/ to estimate the proportion of patients reclassified as having pre-capillary PH when using the new 2022 ESC/ERS hemodynamic criteria (i.e. mPAP 21-24 mmHg and PVR ≥ 2 WU), and to describe their clinical characteristics and outcome; and 2/ to study the relationship between PVR and survival in patients with mPAP > 20 mmHg. Methods We retrospectively analyzed consecutive SSc patients included in our National Reference Center for a first right-heart catheterization between 2003 and 2018. The association between survival and PVR was studied using smoothing splines. Results We included 126 SSc patients with mPAP > 20 mmHg. Among them, 16 (13%) had a baseline mPAP value between 21 and 24 mmHg and PVR ≥ 2 mmHg and were reclassified as pre-capillary PH; 10 of which (62%) raised their mPAP ≥ 25 mmHg during follow-up. In patients with mPAP > 20 mmHg, we observed a linear relation between PVR and mortality for values < 6 WU. Conclusion A significant proportion of SSc patients is reclassified as having pre-capillary PH with the new 2022 ESC/ERS hemodynamic definition. Lowering the PVR threshold from 3 to 2 WU captures patients at risk of raising their mPAP > 25 mmHg, with a possibly less severe disease.Lire moins >
Lire la suite >Background and objective The definition of pre-capillary pulmonary hypertension (PH) has been modified, with lowering of the mean pulmonary arterial pressure (mPAP) threshold from 25 to 20 mmHg and addition of a mandatory criterion of pulmonary vascular resistance (PVR) ≥ 2 Wood units (WU). Our objectives were: 1/ to estimate the proportion of patients reclassified as having pre-capillary PH when using the new 2022 ESC/ERS hemodynamic criteria (i.e. mPAP 21-24 mmHg and PVR ≥ 2 WU), and to describe their clinical characteristics and outcome; and 2/ to study the relationship between PVR and survival in patients with mPAP > 20 mmHg. Methods We retrospectively analyzed consecutive SSc patients included in our National Reference Center for a first right-heart catheterization between 2003 and 2018. The association between survival and PVR was studied using smoothing splines. Results We included 126 SSc patients with mPAP > 20 mmHg. Among them, 16 (13%) had a baseline mPAP value between 21 and 24 mmHg and PVR ≥ 2 mmHg and were reclassified as pre-capillary PH; 10 of which (62%) raised their mPAP ≥ 25 mmHg during follow-up. In patients with mPAP > 20 mmHg, we observed a linear relation between PVR and mortality for values < 6 WU. Conclusion A significant proportion of SSc patients is reclassified as having pre-capillary PH with the new 2022 ESC/ERS hemodynamic definition. Lowering the PVR threshold from 3 to 2 WU captures patients at risk of raising their mPAP > 25 mmHg, with a possibly less severe disease.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
Institut Pasteur de Lille
CHU Lille
Institut Pasteur de Lille
Collections :
- Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
- IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
- Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
- METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Date de dépôt :
2023-10-20T05:59:38Z
2024-02-28T14:59:22Z
2024-02-28T14:59:22Z
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- Puigrenier et al.pdf
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