Title :

Whole pulmonary assessment 1 year after paediatric acute respiratory distress syndrome: prospective multicentre study

Author(s) :

Neve, Veronique [Auteur]
Service d'explorations fonctionnelles respiratoires [Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Institut Pasteur de Lille
Sadik, Ahmed [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Petyt, Laurent [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Dauger, Stéphane [Auteur]
AP-HP Hôpital universitaire Robert-Debré [Paris]
Kheniche, Ahmed [Auteur]
AP-HP Hôpital universitaire Robert-Debré [Paris]
Denjean, André [Auteur]
AP-HP Hôpital universitaire Robert-Debré [Paris]
Léger, Pierre Louis [Auteur]
360410|||CHU Trousseau [APHP] (VALID)
Chalard, François [Auteur]
CHU Trousseau [APHP]
Boulé, Michèle [Auteur]
CHU Trousseau [APHP]
Javouhey, Etienne [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Reix, Philippe [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Canterino, Isabelle [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Deken, Valerie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Service de Biostatistiques [CHRU Lille]
Matran, Regis [Auteur]
Service d'explorations fonctionnelles respiratoires [Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Institut Pasteur de Lille
Leteurtre, Stephane [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Leclerc, Francis [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]

Journal title :

Annals of Intensive Care

Abbreviated title :

Ann Intensive Care

Volume number :

12

Pages :

79

Publisher :

SpringerOpen

Publication date :

2022-08-20

ISSN :

2110-5820

English keyword(s) :

ARDS
Child
Long-term outcomes
Computed tomography
Pulmonary function

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Long-term pulmonary sequelae, including 1-year thoracic computed tomography (CT) sequelae of paediatric acute respiratory distress syndrome (ARDS) remain unknown. The purpose of the study was to determine ...
Show more >Background Long-term pulmonary sequelae, including 1-year thoracic computed tomography (CT) sequelae of paediatric acute respiratory distress syndrome (ARDS) remain unknown. The purpose of the study was to determine pulmonary abnormalities in child survivors of pulmonary (p-ARDS) and extra-pulmonary ARDS (ep-ARDS) 1 year after paediatric intensive care unit discharge (PICUD). Methods Prospective multicentre study in four paediatric academic centres between 2005 and 2014. Patients with ARDS were assessed 1 year after PICUD with respiratory symptom questionnaire, thoracic CT and pulmonary function tests (PFT). Results 39 patients (31 p-ARDS) aged 1.1–16.2 years were assessed. Respiratory symptoms at rest or exercise and/or respiratory maintenance treatment were reported in 23 (74%) of children with p-ARDS but in 1 (13%) of those with ep-ARDS. Thoracic CT abnormalities were observed in 18 (60%) of children with p-ARDS and 4 (50%) of those with ep-ARDS. Diffuse and more important CT abnormalities, such as ground glass opacities or mosaic perfusion patterns, were observed in 5 (13%) of children, all with p-ARDS. PFT abnormalities were observed in 30 (86%) of patients: lung hyperinflation and/or obstructive pattern in 12 (34%) children, restrictive abnormalities in 6 (50%), mild decrease in diffusing capacity in 2 (38%) and 6-min walking distance decrease in 11 (73%). Important PFT abnormalities were observed in 7 (20%) children, all with p-ARDS. Increasing driving pressure (max plateau pressure—max positive end-expiratory pressure) was correlated with increasing CT-scan abnormalities and increasing functional residual capacity (more hyperinflation) (p < 0.005). Conclusions Children surviving ARDS requiring mechanical ventilation present frequent respiratory symptoms, significant CT-scan and PFT abnormalities 1 year after PICUD. This highlights the need for a systematic pulmonary assessment of these children. Trial registration The study was registered on Clinical Trials.gov PRS (ID NCT01435889)Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Other project(s) or funding source(s) :

French Ministry of Health (Programme Hospitalier de Recherche Clinique Régional: 2005R/1906)

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-10-20T06:02:03Z
2024-02-28T09:44:11Z
2024-02-28T09:46:57Z