Aldicarb-related suicide attempt cases in ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Aldicarb-related suicide attempt cases in North of France (2012-2021)
Auteur(s) :
Lenski, Marie [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Letrillart, Agnès [Auteur]
Centre antipoison et de toxicovigilance (Lille) [CAPTV Lille]
Gish, Alexandr [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nisse, Patrick [Auteur]
Centre antipoison et de toxicovigilance (Lille) [CAPTV Lille]
Gaulier, Jean-Michel [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Allorge, Delphine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Letrillart, Agnès [Auteur]
Centre antipoison et de toxicovigilance (Lille) [CAPTV Lille]
Gish, Alexandr [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nisse, Patrick [Auteur]
Centre antipoison et de toxicovigilance (Lille) [CAPTV Lille]
Gaulier, Jean-Michel [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Allorge, Delphine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Titre de la revue :
Toxicology Research
Nom court de la revue :
Toxicol. Res.
Numéro :
11
Pagination :
529–536
Éditeur :
Royal Society of Chemistry
Date de publication :
2022-05-31
ISSN :
2045-452X
Mot(s)-clé(s) en anglais :
aldicarb
poisoning
suicide attempts
poison control center
insecticides
poisoning
suicide attempts
poison control center
insecticides
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Aldicarb, a carbamate pesticide banned in France since 2008, represents a persistent risk of human poisoning. There is no up-to-date picture of aldicarb intentional poisonings associated to detailed diagnosis and clinical ...
Lire la suite >Aldicarb, a carbamate pesticide banned in France since 2008, represents a persistent risk of human poisoning. There is no up-to-date picture of aldicarb intentional poisonings associated to detailed diagnosis and clinical management of cases to evaluate the effect of its ban on intoxication risk reduction, including suicide. This retrospective epidemiological study describes cases of suicidal intoxication from the Hauts-de-France region between 2012 and 2021 and illustrates this situation through one analytically documented case. 60 cases were collected, mostly presenting a pathognomonic symptomatology. Thirty-five victims presented a muscarinic syndrome (58.3%), 14 a nicotinic syndrome (23.3%), and 37 a central nervous system impairment (61.7%). Hospitalization was necessary for 44 cases (73.3%), with 2 fatal evolutions. Diagnosis was based on the blood cholinesterase activities. Among the 25 cases with toxicology results, 45.8% presented a moderate decrease of acetylcholinesterase activity, whereas 87.5% presented a strong decrease of butyrylcholinesterase activity. Blood or urine detection of aldicarb and its metabolites may be considered in therapeutic management, although their quantification is unlikely to change the emergency medical care. Our study updates epidemiology of aldicarb poisoning at a regional level, highlighting a persisting health threatening situation with banned pesticides. More than 65% of national cases occurred in this agricultural area, aldicarb remaining available from storage of previously purchased products. Robust evidence is presented that acute poisoning is an ongoing major global public health challenge. There is a need for continued international efforts in risk reduction, knowledge, and information strategies.Lire moins >
Lire la suite >Aldicarb, a carbamate pesticide banned in France since 2008, represents a persistent risk of human poisoning. There is no up-to-date picture of aldicarb intentional poisonings associated to detailed diagnosis and clinical management of cases to evaluate the effect of its ban on intoxication risk reduction, including suicide. This retrospective epidemiological study describes cases of suicidal intoxication from the Hauts-de-France region between 2012 and 2021 and illustrates this situation through one analytically documented case. 60 cases were collected, mostly presenting a pathognomonic symptomatology. Thirty-five victims presented a muscarinic syndrome (58.3%), 14 a nicotinic syndrome (23.3%), and 37 a central nervous system impairment (61.7%). Hospitalization was necessary for 44 cases (73.3%), with 2 fatal evolutions. Diagnosis was based on the blood cholinesterase activities. Among the 25 cases with toxicology results, 45.8% presented a moderate decrease of acetylcholinesterase activity, whereas 87.5% presented a strong decrease of butyrylcholinesterase activity. Blood or urine detection of aldicarb and its metabolites may be considered in therapeutic management, although their quantification is unlikely to change the emergency medical care. Our study updates epidemiology of aldicarb poisoning at a regional level, highlighting a persisting health threatening situation with banned pesticides. More than 65% of national cases occurred in this agricultural area, aldicarb remaining available from storage of previously purchased products. Robust evidence is presented that acute poisoning is an ongoing major global public health challenge. There is a need for continued international efforts in risk reduction, knowledge, and information strategies.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
Institut Pasteur de Lille
CHU Lille
Institut Pasteur de Lille
Date de dépôt :
2023-10-20T06:03:47Z
2024-02-28T08:58:20Z
2024-02-28T08:58:20Z
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- Lenski et al-1.pdf
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