Title :

Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia

Author(s) :

Quenon, Camille [Auteur]
BioEcoAgro - UMR transfrontalière INRAe - UMRT1158
Hennebelle, Thierry [Auteur]
BioEcoAgro - UMR transfrontalière INRAe - UMRT1158
Butaud, Jean-François [Auteur]
Ho, Raimana [Auteur]
Samaillie, Jennifer [Auteur]
BioEcoAgro - UMR-T 1158
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lehartel, Tamatoa [Auteur]
Riviere, Celine [Auteur]
BioEcoAgro - UMR-T 1158
Siah, Ali [Auteur]
BioEcoAgro - UMR transfrontalière INRAe - UMRT1158
Bonneau, Natacha [Auteur]
BioEcoAgro - UMR transfrontalière INRAe - UMRT1158
Sahpaz, Sevser [Auteur]
BioEcoAgro - UMR-T 1158
Anthérieu, Sébastien [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Lebegue, Nicolas [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Raharivelomanana, Phila [Auteur]
Roumy, Vincent [Auteur]
BioEcoAgro - UMR-T 1158

Journal title :

Life

Volume number :

12

Pages :

733

Publisher :

MDPI

Publication date :

2022-05-14

ISSN :

2075-1729

English keyword(s) :

Society Islands
traditional medicine
phytochemical
antimicrobial
salicylic compounds
Syzygium malaccense

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of the most cited plants among 63 species used to treat “infectious” diseases, with a description of their medicinal uses. ...
Show more >A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of the most cited plants among 63 species used to treat “infectious” diseases, with a description of their medicinal uses. Bibliographical investigations and antimicrobial screening permitted the selection of the botanical species Syzygium malaccense (Myrtaceae) for phytochemical analysis. Leaves of Syzygium malaccense were usually used in mixture with rhizomes of Curcuma longa to treat infectious diseases such as cystitis. The methanolic plant extracts were tested in vitro with an agar microdilution method on 33 bacteria strains and 1 yeast to obtain their Minimal Inhibitory Concentration (MIC), and cytotoxicity against HepG2 cells were evaluated. Antimicrobial synergistic effects of methanolic plant extracts from leaves of Syzygium malaccense and rhizomes from Curcuma longa were also evaluated. The bio-guided isolation of leaf extract from Syzygium malaccense led to the identification of seven alkyl-salicylic acids (anacardic acids or ginkgolic acids C15:0, C15:1, C17:0, C17:1, C17:2, C17:3 and C19:1) described for the first time in this species. All compounds were tested against Staphylococcus aureus (18.75 < MIC < 75.0 µg/mL), Streptococcus pyogenes (2.34 < MIC < 18.75 µg/mL) and Pseudomonas aeruginosa (MIC = 150 µg/mL), and their structure–activity relationships were discussed. The methanolic extract and salicylic derivatives from S. malaccense showed an interesting antimicrobial activity against Gram+ bacteria, without toxicity on hepG2 cells at 400 μg/mL. Moreover, these antibacterial compounds have already been studied for their anti-inflammatory activity, which supports the therapeutic interest of S. malaccense against infectious diseases.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• BioEcoAgro - UMR-T 1158
• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Specialized Metabolites of Plant Origin

Submission date :

2023-10-20T06:05:07Z
2024-02-28T15:22:49Z
2024-02-28T15:26:51Z