Title :

Genome-Wide Association Study of Fluorescent Oxidation Products Accounting for Tobacco Smoking Status in Adults from the French EGEA Study

Author(s) :

Orsi, Laurent [Auteur]
Margaritte-Jeannin, Patricia [Auteur]
Andrianjafimasy, Miora [Auteur]
Dumas, Orianne [Auteur]
Mohamdi, Hamida [Auteur]
Bouzigon, Emmanuelle [Auteur]
Demenais, Florence [Auteur]
Matran, Regis [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut Pasteur de Lille
Zerimech, Farid [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut Pasteur de Lille
Nadif, Rachel [Auteur]
Dizier, Marie-Hélène [Auteur]

Journal title :

Antioxidants

Volume number :

11

Pages :

802

Publisher :

MDPI

Publication date :

2022-04-20

ISSN :

2076-3921

English keyword(s) :

fluorescent oxidation products
oxidative stress
genome-wide association study
chronic diseases
asthma
smoking

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Endocrinologie et métabolisme
Sciences du Vivant [q-bio]/Immunologie/Allergologie
Sciences du Vivant [q-bio]/Génétique/Génétique humaine
Sciences du Vivant [q-bio]/Santé publique et épidémiologie

English abstract : [en]

Oxidative stress (OS) is the main pathophysiological mechanism involved in several chronic diseases, including asthma. Fluorescent oxidation products (FlOPs), a global biomarker of damage due to OS, is of growing interest ...
Show more >Oxidative stress (OS) is the main pathophysiological mechanism involved in several chronic diseases, including asthma. Fluorescent oxidation products (FlOPs), a global biomarker of damage due to OS, is of growing interest in epidemiological studies. We conducted a genome-wide association study (GWAS) of the FlOPs level in 1216 adults from the case-control and family-based EGEA study (mean age 43 years old, 51% women, and 23% current smokers) to identify genetic variants associated with FlOPs. The GWAS was first conducted in the whole sample and then stratified according to smoking status, the main exogenous source of reactive oxygen species. Among the top genetic variants identified by the three GWAS, those located in BMP6 (p = 3 × 10−6), near BMPER (p = 9 × 10−6), in GABRG3 (p = 4 × 10−7), and near ATG5 (p = 2 × 10−9) are the most relevant because of both their link to biological pathways related to OS and their association with several chronic diseases for which the role of OS in their pathophysiology has been pointed out. BMP6 and BMPER are of particular interest due to their involvement in the same biological pathways related to OS and their functional interaction. To conclude, this study, which is the first GWAS of FlOPs, provides new insights into the pathophysiology of chronic OS-related diseases.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Marqueurs biologiques appartenant aux chemins physiopathologiques oxydant et nitrosant en relation avec l'environnement et l'asthme

Other project(s) or funding source(s) :

French National Research Program for Environmental and Occupational Health of Anses (EST/2017/1/158)
National Hospital program of clinical research (PHRC-National 2012, EvAdA)
Fonds AGIR pour les maladies chroniques
Région Hauts de France

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2023-10-20T06:05:33Z
2024-02-28T16:10:50Z