Determination of Orellanine in Human ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
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Titre :
Determination of Orellanine in Human Biological Matrices Using Liquid Chromatography with High-Resolution Mass Spectrometry Detection: A Validated Method Applied to Suspected Poisoning Cases.
Auteur(s) :
Flament, Estelle [Auteur]
Guitton, Jérôme [Auteur]
Université Claude Bernard Lyon 1 - Institut des Sciences Pharmaceutiques et Biologiques [UCBL ISPB]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Gicquel, Thomas [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
Paret, Nathalie [Auteur]
Centre antipoison et de toxicovigilance (Lyon) [CAPTV Lyon]
Jarrier, Nathalie [Auteur]
Laboratoire de Biochimie et Toxicologie [Centre Hospitalier Lyon Sud - HCL]
Creusat, Gaëlle [Auteur]
Centre antipoison et de toxicovigilance (Nancy) [CAPTV Nancy]
Tournoud, Christine [Auteur]
Centre antipoison et de toxicovigilance (Nancy) [CAPTV Nancy]
Labadie, Magali [Auteur]
Centre antipoison et de toxicovigilance (Bordeaux) [CAPTV Bordeaux]
Gaulier, Jean-Michel [Auteur]
Toxicologie et Génopathies [CHRU Lille]
Gaillard, Yvan [Auteur]
Guitton, Jérôme [Auteur]
Université Claude Bernard Lyon 1 - Institut des Sciences Pharmaceutiques et Biologiques [UCBL ISPB]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Gicquel, Thomas [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
Paret, Nathalie [Auteur]
Centre antipoison et de toxicovigilance (Lyon) [CAPTV Lyon]
Jarrier, Nathalie [Auteur]
Laboratoire de Biochimie et Toxicologie [Centre Hospitalier Lyon Sud - HCL]
Creusat, Gaëlle [Auteur]
Centre antipoison et de toxicovigilance (Nancy) [CAPTV Nancy]
Tournoud, Christine [Auteur]
Centre antipoison et de toxicovigilance (Nancy) [CAPTV Nancy]
Labadie, Magali [Auteur]
Centre antipoison et de toxicovigilance (Bordeaux) [CAPTV Bordeaux]
Gaulier, Jean-Michel [Auteur]
Toxicologie et Génopathies [CHRU Lille]
Gaillard, Yvan [Auteur]
Titre de la revue :
Journal of Analytical Toxicology
Nom court de la revue :
J Anal Toxicol
Numéro :
47
Pagination :
26–32
Éditeur :
Oxford University Press (OUP): Policy F
Date de publication :
2022-03-16
ISSN :
0146-4760
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Consumption of mushrooms can become unsafe for the consumer in case of confusion. Some fungi of Cortinarius genus contain the nephrotoxic mycotoxin orellanine responsible for their toxicity. Related case poisoning diagnosis ...
Lire la suite >Consumption of mushrooms can become unsafe for the consumer in case of confusion. Some fungi of Cortinarius genus contain the nephrotoxic mycotoxin orellanine responsible for their toxicity. Related case poisoning diagnosis is a challenge for both clinicians and analysts because of a long latency period between intake and toxic syndrome, the lack of available information in literature and the numerous pitfalls of orellanine identification/quantification in biological samples. In this situation, we propose an analytical method designed for the orellanine detection and/or quantification in biological matrices such as plasma, urine and whole blood, in a context of related intoxication suspected case. Using 1 mL biological sample volume, this liquid chromatographic with high-resolution mass spectrometry detection method (i) exhibits a limit of quantification for orellanine of 0.5 µg/L in plasma and urine and (ii) enables orellanine detection in whole blood with a limit of detection of 0.5 µg/L. This validated analytical method was successfully applied to 10 suspected intoxication cases.Lire moins >
Lire la suite >Consumption of mushrooms can become unsafe for the consumer in case of confusion. Some fungi of Cortinarius genus contain the nephrotoxic mycotoxin orellanine responsible for their toxicity. Related case poisoning diagnosis is a challenge for both clinicians and analysts because of a long latency period between intake and toxic syndrome, the lack of available information in literature and the numerous pitfalls of orellanine identification/quantification in biological samples. In this situation, we propose an analytical method designed for the orellanine detection and/or quantification in biological matrices such as plasma, urine and whole blood, in a context of related intoxication suspected case. Using 1 mL biological sample volume, this liquid chromatographic with high-resolution mass spectrometry detection method (i) exhibits a limit of quantification for orellanine of 0.5 µg/L in plasma and urine and (ii) enables orellanine detection in whole blood with a limit of detection of 0.5 µg/L. This validated analytical method was successfully applied to 10 suspected intoxication cases.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
Institut Pasteur de Lille
CHU Lille
Institut Pasteur de Lille
Collections :
Date de dépôt :
2023-10-20T06:08:43Z
2024-02-26T16:03:29Z
2024-02-26T16:03:29Z
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