Analytical documentation of an Arabian horse fatality related to Oenanthe crocata poisoning

Gish, Alexandr; Robveille, Cynthia; Gicquel, Thomas; Allorge, Delphine; Gault, Gilbert; Gaulier, Jean-Michel

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.toxicon.2022.02.009

PMID :

35189181

Permalink :

http://hdl.handle.net/20.500.12210/88440

Title :

Analytical documentation of an Arabian horse fatality related to Oenanthe crocata poisoning

Author(s) :

Gish, Alexandr [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Robveille, Cynthia [Auteur]
École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique [ONIRIS]
Gicquel, Thomas [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Allorge, Delphine [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Gault, Gilbert [Auteur]
Ecole Nationale Vétérinaire de Lyon [ENVL]
Gaulier, Jean-Michel [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]

Journal title :

Toxicon

Volume number :

210

Pages :

39-43

Publisher :

Elsevier

Publication date :

2022-02-18

ISSN :

0041-0101

English keyword(s) :

Oenanthe crocata poisoning
Horse
Oenanthotoxin
2,3-dihydro-oenanthotoxin
LC-HRMS
LC-DAD

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Analytical detection of Oenanthe crocata toxins in biological samples is challenging because of their instability, the lack of commercially available standards and the exceptionally low detection of these molecules using ...
Show more >Analytical detection of Oenanthe crocata toxins in biological samples is challenging because of their instability, the lack of commercially available standards and the exceptionally low detection of these molecules using mass spectrometry. This work aims to report the used analytical methods that allowed identification of the main plant toxins in biological samples from an equid (an Arabian horse) fatality related to hemlock water dropwort (Oenanthe crocata Linnaeus) intake. Using both LC-DAD and LC-HRMS methods allowed identification (i) of oenanthotoxin in roots found on the site, root fragments found in the stomach, stomach content, kidney, and liver, and (ii) of the hydrogenated metabolite of oenanthotoxin (2,3-dihydro-oenanthotoxin) in roots found on the site, root fragments found in the stomach, stomach content, kidney, liver and spleen. Reported analytical data about Oenanthe crocata toxins can be useful for identification of the ingested plant and for supporting a poisoning diagnosis in such cases.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2023-10-20T06:09:50Z
2024-02-23T10:07:43Z

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2	20.500.12210/88440*	2024-02-23T09:56:46Z
1	20.500.12210/88440.1	2023-10-20T06:09:50Z

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