Title :

Hair analysis interpretation in post-mortem situations: Key considerations and proposals to overcome main hurdles

Author(s) :

Benhalima, Ilyes [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Castex, Eugénie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Dumont, Guillaume [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Gish, Alexandr [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hakim, Florian [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Allorge, Delphine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Gaulier, Jean-Michel [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Journal title :

Legal Medicine

Abbreviated title :

Leg Med (Tokyo)

Volume number :

56

Pages :

102032

Publisher :

Elsevier

Publication date :

2022-02-01

ISSN :

1344-6223

English keyword(s) :

Forensic
Hair analysis
Post-mortem
Contamination

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

In the analytical challenge of post-mortem toxicological investigations of victim’s drug history, hair analysis constitutes a useful tool. Nevertheless, in addition to usual limitations of hair result interpretation, there ...
Show more >In the analytical challenge of post-mortem toxicological investigations of victim’s drug history, hair analysis constitutes a useful tool. Nevertheless, in addition to usual limitations of hair result interpretation, there are additional pitfalls in post-mortem situations. This manuscript aims to address post-mortem hair analysis interpretation difficulties and proposals to overcome them. In post-mortem situations, mainly in cases of putrefaction, additional interpretation pitfalls are related to contamination issues consisting in drug incorporation into hair at the time of death (in case of intoxication and excessive sweating) and/or during the post-mortem period by putrefaction fluids. To overcome these issues, conventionally accepted criteria and considerations that must be taken into account encompass knowledge of death circumstances, confidence in analytical results, hair decontamination steps, segmental hair analysis, concentration consideration (values and hair concentration pattern), bath wash analysis results and observed parent drug/metabolites ratio. Nevertheless, none of these proposals is able to formally discriminate positive hair results related to intakes by the victim in the weeks or months before death, from hair contaminations (including those that occurred at the time of death and/or during the post-mortem period). A promising option could be to associate nails analysis to hair ones.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2023-10-20T06:10:50Z
2024-02-23T08:52:05Z
2024-02-26T10:35:48Z