Titre :

PID1 is associated to a respiratory endotype related to occupational exposures to irritants.

Auteur(s) :

Andrianjafimasy, Miora [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Orsi, Laurent [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Margaritte-Jeannin, Patricia [Auteur]
Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
Mohamdi, Hamida [Auteur]
Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
Demenais, Florence [Auteur]
Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
Lemoual, Nicole [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Matran, Regis [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Zerimech, Farid [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Dumas, Orianne [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Dizier, Marie-Hélène [Auteur]
Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
Nadif, Rachel [Auteur]

Titre de la revue :

Free Radical Biology and Medicine

Nom court de la revue :

Free Radic Biol Med

Numéro :

172

Pagination :

503-507

Éditeur :

Elsevier

Date de publication :

2021-06-10

ISSN :

1873-4596

Mot(s)-clé(s) en anglais :

Oxidative stress
Asthma
Endotypes
Gene association study
Occupational exposure
Irritants

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Studying associations between genes and asthma endotypes and interactions with environment could help to identify new susceptibility genes. We used a previously identified asthma endotype characterized by ...
Lire la suite >Background Studying associations between genes and asthma endotypes and interactions with environment could help to identify new susceptibility genes. We used a previously identified asthma endotype characterized by adult-onset asthma, poor lung function, and high level of Fluorescent oxidation products, a marker of damages due to oxidative stress. This endotype was associated with high occupational exposure to irritants. We aimed to investigate the associations between genes related to oxidative stress and this endotype, and if the associations differed according to irritants exposure. Methods We conducted association analyses between the asthma endotype and genetic variants (4715 SNPs) located in 422 genes involved in the “response to oxidative stress” in adults from the Epidemiological study on the Genetic and Environment of Asthma. Analyses using logistic regression were conducted first in all participants, and then separately among high vs. non-exposed participants to assess whether association differs according to irritants exposure. Results An association was found between the SNP rs1419958 located in PID1 gene and the endotype (P = 2.2E-05), reaching significance level after correction for multiple testing. This association was even more significant in non-exposed participants (P = 1.06E-06) while there was no association in participants with high exposure to occupational irritants. Conclusion This study showed a significant association between an asthma endotype and PID1, a promising candidate gene, the association being different according to the exposure to irritants. These results highlight the interest of studying asthma endotypes in association with genes from candidate pathways and their link with occupational irritants to decipher asthma etiology.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Date de dépôt :

2023-10-20T06:16:42Z
2023-12-20T09:07:55Z