Muscle oxygen supply impairment during ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy.
Author(s) :
Machfer, Amal [Auteur]
Université de Sfax
Tagougui, Sémah [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Fekih, Nadia [Auteur]
Université de Sfax
Ben Haj Hassen, Haya [Auteur]
Université de Sfax
Amor, Hassen Hadj [Auteur]
Bouzid, Mohamed Amine [Auteur]
Université de Sfax
Chtourou, Hamdi [Auteur]
University of Tunis El Manar
Université de Sfax
Tagougui, Sémah [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Fekih, Nadia [Auteur]
Université de Sfax
Ben Haj Hassen, Haya [Auteur]
Université de Sfax
Amor, Hassen Hadj [Auteur]
Bouzid, Mohamed Amine [Auteur]
Université de Sfax
Chtourou, Hamdi [Auteur]
University of Tunis El Manar
Journal title :
Respiratory Physiology & Neurobiology
Abbreviated title :
Respir Physiol Neurobiol
Volume number :
319
Pages :
104169
Publisher :
Elsevier
Publication date :
2023-10-14
ISSN :
1878-1519
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis ...
Show more >This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incremental exercise test to determine maximal oxygen uptake (VO2peak). Throughout the exercise, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O2Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the vastus lateralis muscle. VO2peak was significantly lower in HD group. In addition, HD patients had impaired changes in muscular oxygenation (∆HHb and ∆O2Hb) and blood volume (∆THb) during the exercise (p < 0.05). Moreover, a positive correlation was observed between VO2peak and muscle blood volume (∆THb) in both groups (p < 0.05). This study provides the first evidence that HD patients displayed lower VO2peak and blunted muscular deoxyhemoglobin increase during exercise. This result supports the hypothesis of an increase in oxygen affinity and/or mitochondrial dysfunction in this population.Show less >
Show more >This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incremental exercise test to determine maximal oxygen uptake (VO2peak). Throughout the exercise, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O2Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the vastus lateralis muscle. VO2peak was significantly lower in HD group. In addition, HD patients had impaired changes in muscular oxygenation (∆HHb and ∆O2Hb) and blood volume (∆THb) during the exercise (p < 0.05). Moreover, a positive correlation was observed between VO2peak and muscle blood volume (∆THb) in both groups (p < 0.05). This study provides the first evidence that HD patients displayed lower VO2peak and blunted muscular deoxyhemoglobin increase during exercise. This result supports the hypothesis of an increase in oxygen affinity and/or mitochondrial dysfunction in this population.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale
Univ. Artois
Univ. Littoral Côte d’Opale
Research team(s) :
Activité Physique, Muscle, Santé (APMS)
Submission date :
2023-10-20T07:03:32Z
2023-11-29T08:43:25Z
2024-04-04T23:57:43Z
2023-11-29T08:43:25Z
2024-04-04T23:57:43Z