Title :

Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy.

Author(s) :

Machfer, Amal [Auteur]
Université de Sfax
Tagougui, Sémah [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Fekih, Nadia [Auteur]
Université de Sfax
Ben Haj Hassen, Haya [Auteur]
Université de Sfax
Amor, Hassen Hadj [Auteur]
Bouzid, Mohamed Amine [Auteur]
Université de Sfax
Chtourou, Hamdi [Auteur]
University of Tunis El Manar

Journal title :

Respiratory Physiology & Neurobiology

Abbreviated title :

Respir Physiol Neurobiol

Volume number :

319

Pages :

104169

Publisher :

Elsevier

Publication date :

2023-10-14

ISSN :

1878-1519

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis ...
Show more >This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incremental exercise test to determine maximal oxygen uptake (VO2peak). Throughout the exercise, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O2Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the vastus lateralis muscle. VO2peak was significantly lower in HD group. In addition, HD patients had impaired changes in muscular oxygenation (∆HHb and ∆O2Hb) and blood volume (∆THb) during the exercise (p < 0.05). Moreover, a positive correlation was observed between VO2peak and muscle blood volume (∆THb) in both groups (p < 0.05). This study provides the first evidence that HD patients displayed lower VO2peak and blunted muscular deoxyhemoglobin increase during exercise. This result supports the hypothesis of an increase in oxygen affinity and/or mitochondrial dysfunction in this population.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Research team(s) :

Activité Physique, Muscle, Santé (APMS)

Submission date :

2023-10-20T07:03:32Z
2023-11-29T08:43:25Z
2024-04-04T23:57:43Z