Titre :

Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy.

Auteur(s) :

Machfer, Amal [Auteur]
Université de Sfax
Tagougui, Sémah [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Fekih, Nadia [Auteur]
Université de Sfax
Ben Haj Hassen, Haya [Auteur]
Université de Sfax
Amor, Hassen Hadj [Auteur]
Bouzid, Mohamed Amine [Auteur]
Université de Sfax
Chtourou, Hamdi [Auteur]
University of Tunis El Manar

Titre de la revue :

Respiratory Physiology & Neurobiology

Nom court de la revue :

Respir Physiol Neurobiol

Numéro :

319

Pagination :

104169

Éditeur :

Elsevier

Date de publication :

2023-10-14

ISSN :

1878-1519

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis ...
Lire la suite >This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incremental exercise test to determine maximal oxygen uptake (VO2peak). Throughout the exercise, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O2Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the vastus lateralis muscle. VO2peak was significantly lower in HD group. In addition, HD patients had impaired changes in muscular oxygenation (∆HHb and ∆O2Hb) and blood volume (∆THb) during the exercise (p < 0.05). Moreover, a positive correlation was observed between VO2peak and muscle blood volume (∆THb) in both groups (p < 0.05). This study provides the first evidence that HD patients displayed lower VO2peak and blunted muscular deoxyhemoglobin increase during exercise. This result supports the hypothesis of an increase in oxygen affinity and/or mitochondrial dysfunction in this population.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Équipe(s) de recherche :

Activité Physique, Muscle, Santé (APMS)

Date de dépôt :

2023-10-20T07:03:32Z
2023-11-29T08:43:25Z
2024-04-04T23:57:43Z