Title :

Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System

Author(s) :

Latreche, Mansour [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
willart, Jean-François [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Journal title :

Pharmaceutics

Abbreviated title :

Pharmaceutics

Volume number :

15

Pages :

1505

Publisher :

MDPI AG

Publication date :

2023-05-15

ISSN :

1999-4923

English keyword(s) :

dissolution
solubility
drug
polymer
crystal
amorphous
temperature modulated DSC
diffusion

HAL domain(s) :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

English abstract : [en]

This paper is dealing with the dissolution mechanism of crystalline sulindac into amorphous Polyvinylpyrrolidone (PVP) upon heating and annealing at high temperatures. Special attention is paid on the diffusion mechanism ...
Show more >This paper is dealing with the dissolution mechanism of crystalline sulindac into amorphous Polyvinylpyrrolidone (PVP) upon heating and annealing at high temperatures. Special attention is paid on the diffusion mechanism of drug molecules in the polymer which leads to a homogeneous amorphous solid dispersion of the two components. The results show that isothermal dissolution proceeds through the growth of polymer zones saturated by the drug, and not by a progressive increase in the uniform drug concentration in the whole polymer matrix. The investigations also show the exceptional ability of temperature Modulated Differential Scanning Calorimetry (MDSC) to identify the equilibrium and out of equilibrium stages of dissolution corresponding to the trajectory of the mixture into its state diagram.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2023-11-08T13:30:20Z
2023-11-08T16:08:53Z
2023-11-10T09:00:28Z
2023-11-10T09:01:15Z