Title :

PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry

Author(s) :

Wachowiak, S. [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Danede, Florence [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Willart, Jean-François [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Hamoudi, M. [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]

Journal title :

Journal of Drug Delivery Science and Technology

Abbreviated title :

Journal of Drug Delivery Science and Technology

Volume number :

86

Pages :

104648

Publisher :

Elsevier BV

Publication date :

2023-09

ISSN :

1773-2247

English keyword(s) :

PLGA
implants
controlled release
dexamethasone
swelling

HAL domain(s) :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

English abstract : [en]

The aim of this study was to better understand the impact of the chemistry of poly(lactic-co-glycolic acid) (PLGA) polymers on the resulting drug release kinetics from implants prepared by melting and molding. Dexamethasone ...
Show more >The aim of this study was to better understand the impact of the chemistry of poly(lactic-co-glycolic acid) (PLGA) polymers on the resulting drug release kinetics from implants prepared by melting and molding. Dexamethasone was incorporated as the drug. The polymer molecular weight of the PLGA, lactic acid:glycolic acid ratio and type of end groups (ester versus free acid) were varied. The implants were characterized using optical macroscopy, SEM, X-ray powder diffraction, DSC, gravimetric monitoring of dynamic changes in the systems’ dry and wet mass upon exposure to the release medium as well as drug release and pH measurements. Interestingly, the shape of the drug release profiles was similar in all cases: No noteworthy burst effect was observed. Dexamethasone release set on after a lag time, the length of which strongly depended on the PLGA chemistry: The lag time decreased with decreasing polymer molecular weight, increasing glycolic acid content and was shorter for –COOH end groups compared to ester end groups. In all cases, drug release set on as soon as a critical hydrophilicity and polymer molecular weight were reached and substantial system swelling started: The penetration of large amounts of water into the implants allowed for complete dexamethasone dissolution and relatively rapid diffusion of the dissolved drug molecules through a highly swollen PLGA gel up to 100% drug release.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2023-11-08T13:42:47Z
2023-11-21T09:32:10Z
2024-04-02T07:44:00Z
2024-04-02T07:48:12Z
2024-04-02T08:12:31Z
2024-04-02T13:40:12Z
2024-04-29T08:59:32Z