Title :

Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma

Author(s) :

Gavala, M L [Auteur]
Kelly, E A B [Auteur]
Esnault, Stéphane [Auteur]
University of Wisconsin School of Medicine and Public Health
Kukreja, S [Auteur]
Evans, M D [Auteur]
Bertics, P J [Auteur]
Chupp, G L [Auteur]
Jarjour, N N [Auteur]

Journal title :

Clinical and Experimental Allergy

Abbreviated title :

Clin Exp Allergy

Volume number :

43

Pages :

187-97

Publication date :

2013-02-01

ISSN :

1365-2222

English keyword(s) :

Adipokines
Adult
Airway Remodeling
Allergens
Asthma
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid
Chemokines, CC
Chitinase-3-Like Protein 1
Chitinases
Cytokines
Enzyme Activation
Female
Humans
Inflammation Mediators
Lectins
Male
Time Factors
Young Adult

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Allergic airway inflammation contributes to the airway remodelling that has been linked to increased obstruction and morbidity in asthma. However, the mechanisms by which allergens contribute to airway remodelling in humans ...
Show more >Allergic airway inflammation contributes to the airway remodelling that has been linked to increased obstruction and morbidity in asthma. However, the mechanisms by which allergens contribute to airway remodelling in humans are not fully established. CCL18, chitotriosidase (CHIT1) and YKL-40 are readily detectable in the lungs and contribute to remodelling in other fibrotic diseases, but their involvement in allergic asthma is unclear. We hypothesized that CCL18, YKL-40 and CHIT1 bioactivity are enhanced in allergic asthma subjects after segmental allergen challenge and are related to increased pro-fibrotic and Th2-associated mediators in the lungs. Levels of CCL18 and YKL-40 protein and chitotriosidase (CHIT1) bioactivity in bronchoalveolar lavage (BAL) fluid, as well as CCL18, YKL-40 and CHIT1 mRNA levels in BAL cells were evaluated in patients with asthma at baseline and 48 h after segmental allergen challenge. We also examined the correlation between CCL18 and YKL-40 levels and CHIT1 activity with the levels of other pro-fibrotic factors and chemokines previously shown to be up-regulated after allergen challenge. Chitotriosidase activity and YKL-40 and CCL18 levels were elevated after segmental allergen challenge and these levels correlated with those of other pro-fibrotic factors, T cell chemokines, and inflammatory cells after allergen challenge. CCL18 and YKL-40 mRNA levels also increased in BAL cells after allergen challenge. Our results suggest that CCL18 and YKL-40 levels and CHIT1 activity are enhanced in allergic airway inflammation and thus may contribute to airway remodelling in asthma.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2023-11-10T15:38:08Z
2024-03-06T10:41:51Z
2024-06-17T11:22:35Z