Pinning down signaling in the immune system: ...
Type de document :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
URL permanente :
Titre :
Pinning down signaling in the immune system: the role of the peptidyl-prolyl isomerase Pin1 in immune cell function.
Auteur(s) :
Esnault, Stéphane [Auteur]
University of Wisconsin School of Medicine and Public Health
Shen, Zong-Jian [Auteur]
University of Wisconsin School of Medicine and Public Health
Malter, James S [Auteur]
University of Wisconsin School of Medicine and Public Health
University of Wisconsin School of Medicine and Public Health
Shen, Zong-Jian [Auteur]
University of Wisconsin School of Medicine and Public Health
Malter, James S [Auteur]
University of Wisconsin School of Medicine and Public Health
Titre de la revue :
Critical Reviews in Immunology
Nom court de la revue :
Crit Rev Immunol
Numéro :
28
Pagination :
45-60
Éditeur :
Begell House
Date de publication :
2008-02-01
Statut de l’article :
Publié
ISSN :
1040-8401
Mot(s)-clé(s) en anglais :
Animals
Apoptosis
B-Lymphocytes
Cytokines
Immune System
Peptidylprolyl Isomerase
Signal Transduction
T-Lymphocytes
Tacrolimus Binding Proteins
Apoptosis
B-Lymphocytes
Cytokines
Immune System
Peptidylprolyl Isomerase
Signal Transduction
T-Lymphocytes
Tacrolimus Binding Proteins
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle control and neuropathologies. There is now growing evidence that Pin1 plays an important role in the immune system and does so ...
Lire la suite >The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle control and neuropathologies. There is now growing evidence that Pin1 plays an important role in the immune system and does so differentially from the related PPIases, cyclophilinA and FKBP. This review describes how Pin1 modulates cytokine expression by activated T cells and eosinophils and participates in T-cell and eosinophil apoptotic decisions both in vitro and in vivo. We highlight several possible immunologic diseases, including asthma, as well as organ transplant rejection, where anti-Pin1 therapeutics maybe of value.Lire moins >
Lire la suite >The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle control and neuropathologies. There is now growing evidence that Pin1 plays an important role in the immune system and does so differentially from the related PPIases, cyclophilinA and FKBP. This review describes how Pin1 modulates cytokine expression by activated T cells and eosinophils and participates in T-cell and eosinophil apoptotic decisions both in vitro and in vivo. We highlight several possible immunologic diseases, including asthma, as well as organ transplant rejection, where anti-Pin1 therapeutics maybe of value.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Date de dépôt :
2023-11-14T11:08:15Z
2024-05-30T12:50:32Z
2024-05-30T12:50:32Z
Fichiers
- Pin-1 review 2008 CRI2801 (45-60).pdf
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