Antibiotic treatment of Neuro-meningeal ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
Permalink :
Title :
Antibiotic treatment of Neuro-meningeal infections.
Author(s) :
Gillet, Y. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Grimprel, E. [Auteur]
Université Paris Cité [UPCité]
Haas, H. [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Yaghy, M. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Dubos, Francois [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Cohen, R. [Auteur]
Centre Hospitalier Intercommunal de Créteil [CHIC]
Université Claude Bernard Lyon 1 [UCBL]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Grimprel, E. [Auteur]
Université Paris Cité [UPCité]
Haas, H. [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Yaghy, M. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Dubos, Francois [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Cohen, R. [Auteur]
Centre Hospitalier Intercommunal de Créteil [CHIC]
Journal title :
Infectious Diseases Now
Abbreviated title :
Infect Dis Now
Volume number :
53
Pages :
104788
Publication date :
2023-11
ISSN :
2666-9919
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
In France, conjugated pneumococcal vaccination has considerably modified the profile of pneumococcal meningitis by eliminating the most virulent strains resistant to beta-lactams. Over recent years, the nationwide pediatric ...
Show more >In France, conjugated pneumococcal vaccination has considerably modified the profile of pneumococcal meningitis by eliminating the most virulent strains resistant to beta-lactams. Over recent years, the nationwide pediatric meningitis network of the Pediatric Infectious Disease Group (GPIP) and the National Reference Centre of Pneumococci have not recorded any cases of meningitis due to pneumococcus resistant to third-generation cephalosporins (C3G), even though in 2021, strains with a less favorable profile appeared to emerge. These recent data justify renewal of the 2016 recommendations and limitation of vancomycin to the secondary phase of treatment of pneumococcal meningitis when the MIC of the isolated strain against injectable C3Gs is >0.5 mg/L. The only major change proposed by the GPIP in this 2023 update of its recommendations is discontinuation of the recommendation of a combination of ciprofloxacin and cefotaxime in Escherichia coli meningitis in newborns and young infants. The nationwide observatory of meningitis in children is a valuable tool because of its completeness and its continuity over the past 15 years. The maintenance of epidemiological surveillance will allow us to adapt new therapeutic regimens to the evolution of pneumococcal susceptibility profiles and to future serotype-specific changes. Community-acquired cerebral abscesses are rare diseases, of which the management requires a rigorous approach: high-quality imaging, bacteriological sampling prior to antibiotic therapy whenever possible, and antibiotic treatment including metronidazole in addition to cefotaxime. Multidisciplinary collaboration, including infectious disease and neurosurgical advice, is always called for.Show less >
Show more >In France, conjugated pneumococcal vaccination has considerably modified the profile of pneumococcal meningitis by eliminating the most virulent strains resistant to beta-lactams. Over recent years, the nationwide pediatric meningitis network of the Pediatric Infectious Disease Group (GPIP) and the National Reference Centre of Pneumococci have not recorded any cases of meningitis due to pneumococcus resistant to third-generation cephalosporins (C3G), even though in 2021, strains with a less favorable profile appeared to emerge. These recent data justify renewal of the 2016 recommendations and limitation of vancomycin to the secondary phase of treatment of pneumococcal meningitis when the MIC of the isolated strain against injectable C3Gs is >0.5 mg/L. The only major change proposed by the GPIP in this 2023 update of its recommendations is discontinuation of the recommendation of a combination of ciprofloxacin and cefotaxime in Escherichia coli meningitis in newborns and young infants. The nationwide observatory of meningitis in children is a valuable tool because of its completeness and its continuity over the past 15 years. The maintenance of epidemiological surveillance will allow us to adapt new therapeutic regimens to the evolution of pneumococcal susceptibility profiles and to future serotype-specific changes. Community-acquired cerebral abscesses are rare diseases, of which the management requires a rigorous approach: high-quality imaging, bacteriological sampling prior to antibiotic therapy whenever possible, and antibiotic treatment including metronidazole in addition to cefotaxime. Multidisciplinary collaboration, including infectious disease and neurosurgical advice, is always called for.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Submission date :
2023-11-15T01:38:07Z
2023-12-22T10:19:17Z
2023-12-22T10:19:17Z