Title :

Relationship between COVID-19 and ICU-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter before-after study.

Author(s) :

Kreitmann, Louis [Auteur]
Hospices Civils de Lyon [HCL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Jermoumi, Sonia [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Vasseur, Margot [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Chabani, Myriam [Auteur]
Hospices Civils de Lyon [HCL]
Nourry, Emilie [Auteur]
Hospices Civils de Lyon [HCL]
Richard, Jean-Christophe [Auteur]
Hospices Civils de Lyon [HCL]
Wallet, Florent [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hospices Civils de Lyon [HCL]
Garçon, Pierre [Auteur]
Grand Hôpital de l'Est Francilien [GHEF]
Kachmar, Safaâ [Auteur]
Grand Hôpital de l'Est Francilien [GHEF]
Zerbib, Yoann [Auteur]
CHU Amiens-Picardie
Van Grunderbeeck, Nicolas [Auteur]
Centre Hospitalier de Lens
Vinsonneau, Christophe [Auteur]
Centre Hospitalier de Béthune [CH Béthune]
Duhamel, Alain [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Labreuche, Julien [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Nseir, Saad [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]

Journal title :

Intensive Care Medicine

Abbreviated title :

Intensive Care Med

Publication date :

2023-06-16

ISSN :

1432-1238

English keyword(s) :

Patient isolation
Cross infection
Intensive care unit
COVID-19
Antimicrobial resistance

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Purpose Patients presenting the most severe form of coronavirus disease 2019 (COVID-19) pneumonia, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have a prolonged intensive care unit (ICU) ...
Show more >Purpose Patients presenting the most severe form of coronavirus disease 2019 (COVID-19) pneumonia, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have a prolonged intensive care unit (ICU) stay and are exposed to broad-spectrum antibiotics, but the impact of COVID-19 on antimicrobial resistance is unknown. Methods Observational prospective before-after study in 7 ICUs in France. All consecutive patients with an ICU stay > 48 h and a confirmed SARS-CoV-2 infection were included prospectively and followed for 28 days. Patients underwent systematic screening for colonization with multidrug-resistant (MDR) bacteria upon admission and every week subsequently. COVID-19 patients were compared to a recent prospective cohort of control patients from the same ICUs. The primary objective was to investigate the association of COVID-19 with the cumulative incidence of a composite outcome including ICU-acquired colonization and/or infection related to MDR bacteria (ICU-MDR-col and ICU-MDR-inf, respectively). Results From February 27th, 2020 to June 2nd, 2021, 367 COVID-19 patients were included, and compared to 680 controls. After adjustment for prespecified baseline confounders, the cumulative incidence of ICU-MDR-col and/or ICU-MDR-inf was not significantly different between groups (adjusted sub-hazard ratio [sHR] 1.39, 95% confidence interval [CI] 0.91–2.09). When considering both outcomes separately, COVID-19 patients had a higher incidence of ICU-MDR-inf than controls (adjusted sHR 2.50, 95% CI 1.90–3.28), but the incidence of ICU-MDR-col was not significantly different between groups (adjusted sHR 1.27, 95% CI 0.85–1.88). Conclusion COVID-19 patients had an increased incidence of ICU-MDR-inf compared to controls, but the difference was not significant when considering a composite outcome including ICU-MDR-col and/or ICU-MDR-inf.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T01:47:21Z
2024-04-04T13:11:37Z