Title :

A French study of cocaine intoxication/exposure in children (2010-2020).

Author(s) :

Claudet, Isabelle [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Caula, Caroline [Auteur]
Hôpital Robert Debré
Gallart, Jean-Christophe [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Tourniaire, Gaëlle [Auteur]
CHU Montpellier = Montpellier University Hospital
Lerouge-Bailhache, Marion [Auteur]

Michard-Lenoir, Anne-Pascale [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Tran, Antoine [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Maleterre, Aline [Auteur]
CHI Créteil
Huet, Frédéric [Auteur]
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand [CHU Dijon]
Dufour, Damien [Auteur]
Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) [GHH]
Billaud, Nicolas [Auteur]
Centre hospitalier régional Metz-Thionville [CHR Metz-Thionville]
David, Alexandra [Auteur]
Di Patrizio, Marie [Auteur]
Centre Hospitalier Universitaire de Nancy [CHU Nancy]
Granjon, Mathilde [Auteur]
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Benoist, Grégoire [Auteur]
Hôpital Ambroise Paré [AP-HP]
Laguille, Christophe [Auteur]
Service d'Urgences pédiatriques médico-chirurgicales [CHU Limoges]
Guitteny, Marie-Aline [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Balençon, Martine [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Vrignaud, Bénédicte [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Basmaci, Romain [Auteur]
Hôpital Louis Mourier - AP-HP [Colombes]
Dampfhoffer, Marie [Auteur]
Centre Hospitalier Métropole Savoie [Chambéry]
Dubos, Francois [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Chappuy, Hélène [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Minodier, Philippe [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
Médiamolle, Nicolas [Auteur]
Hôpital Trousseau
Bréhin, Camille [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]

Journal title :

Clinical toxicology (Philadelphia, Pa.)

Abbreviated title :

Clin Toxicol (Phila)

Pages :

1-9

Publication date :

2023-05-17

ISSN :

1556-9519

English keyword(s) :

pediatrics
intoxication
crack
Cocaine

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background and Objective In the European Union, the record of cocaine-related seizures indicates an expanding supply. The purity has also been increasing. The health impact of these trends remains poorly documented, in ...
Show more >Background and Objective In the European Union, the record of cocaine-related seizures indicates an expanding supply. The purity has also been increasing. The health impact of these trends remains poorly documented, in particular, the changes and clinical manifestations of intoxication in young children. We attempted to evaluate the trend in French pediatric admissions for cocaine intoxication/exposure over an 11-year period (2010–2020). Methods A retrospective, national, multicenter, study of a pediatric cohort. All children less than 15 years of age admitted to a tertiary-level pediatric emergency unit for proven cocaine intoxication (compatible symptoms and positive toxicological screening) during the reference period were included. Results Seventy-four children were included. Forty-six percent were less than 6 years old. Annual admissions increased by a factor of 8 over 11 years (+700%) and 57% of all cases were admitted in the last two years. The main clinical signs were neurologic (59%) followed by cardiovascular symptoms (34%). Twelve patients were transferred to the pediatric intensive care unit. Factors significantly associated with the risk of being transferred to the pediatric intensive care unit were initial admission to the pediatric resuscitation area (P < 0.001), respiratory impairment (P < 0.01), mydriasis (P < 0.01), cardiovascular symptoms (P = 0.014), age of less than 2 years (P = 0.014). Blood and/or urine toxicological screening isolated eighteen other substances besides cocaine in 46 children (66%). Conclusion Children are collateral victims of the changing trends in cocaine availability, use and purity. Admissions of intoxicated children to pediatric emergency departments are more frequent and there is an increase in severe presentations. Therefore, this is a growing public health concern.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T01:59:11Z
2024-03-29T10:33:46Z