Titre :

Antibody response, associated symptoms and profile of patients presumably infected by SARS-CoV-2 with taste or smell disorders in the SAPRIS multicohort study.

Auteur(s) :

Ramillon, Julien [Auteur]
CHU Saint-Antoine [AP-HP]
De Lamballerie, Xavier [Auteur]
Institut Hospitalier Universitaire Méditerranée Infection [IHU Marseille]
Robineau, Olivier [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Blanché, Hélène [Auteur]
Centre d'Etude du Polymorphisme Humain [CEPH]
Severi, Gianluca [Auteur]
Università degli Studi di Firenze = University of Florence = Université de Florence [UniFI]
Institut Gustave Roussy [IGR]
Touvier, Mathilde [Auteur]
Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle [EREN [CRESS - U1153 / UMR_A 1125]]
Zins, Marie [Auteur]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Carrat, Fabrice [Auteur]
CHU Saint-Antoine [AP-HP]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Lapidus, Nathanaël [Auteur]
CHU Saint-Antoine [AP-HP]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]

Titre de la revue :

BMC Infectious Diseases

Nom court de la revue :

BMC Infect Dis

Numéro :

23

Pagination :

228

Date de publication :

2023-04-20

ISSN :

1471-2334

Mot(s)-clé(s) en anglais :

SARS-CoV-2
COVID-19 serological testing
Smell disorders
Taste disorders
General population

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Taste or smell disorders have been reported as strongly associated with COVID-19 diagnosis. We aimed to identify subject characteristics, symptom associations, and antibody response intensity associated with ...
Lire la suite >Background Taste or smell disorders have been reported as strongly associated with COVID-19 diagnosis. We aimed to identify subject characteristics, symptom associations, and antibody response intensity associated with taste or smell disorders. Methods We used data from SAPRIS, a study based on a consortium of five prospective cohorts gathering 279,478 participants in the French general population. In the analysis, we selected participants who were presumably infected by SARS-CoV-2 during the first epidemic wave. Results The analysis included 3,439 patients with a positive ELISA-Spike. Sex (OR = 1.28 [95% CI 1.05–1.58] for women), smoking (OR = 1.54 [95% CI 1.13–2.07]), consumption of more than 2 drinks of alcohol a day (OR = 1.37 [95% CI 1.06–1.76]) were associated with a higher probability of taste or smell disorders. The relationship between age and taste or smell disorders was non-linear. Serological titers were associated with taste or smell disorders: OR = 1.31 [95% CI 1.26–1.36], OR = 1.37 [95% CI 1.33–1.42] and OR = 1.34 [95% CI 1.29–1.39] for ELISA-Spike, ELISA-Nucleocapsid and seroneutralization, respectively. Among participants with taste or smell disorders, 90% reported a wide variety of other symptoms whereas 10% reported no other symptom or only rhinorrhea. Conclusions Among patients with a positive ELISA-Spike test, women, smokers and people drinking more than 2 drinks a day were more likely to develop taste or smell disorders. This symptom was strongly associated with an antibody response. The overwhelming majority of patients with taste or smell disorders experienced a wide variety of symptoms.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T02:09:00Z
2024-04-15T08:28:14Z