Pain in desmoid-type fibromatosis: prevalence, ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
Permalink :
Title :
Pain in desmoid-type fibromatosis: prevalence, determinants, and prognosis value.
Author(s) :
Penel, Nicolas [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Bonvalot, Sylvie [Auteur]
Institut Curie [Paris]
Le Deley, Marie-Cécile [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Italiano, Antoine [Auteur]
Institut Bergonié [Bordeaux]
Tlemsani, Camille [Auteur]
Hôpital Cochin [AP-HP]
Pannier, Diane [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Leguillette, Clémence [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Kurtz, Jean-Emmanuel [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Toulmonde, Maud [Auteur]
Institut Bergonié [Bordeaux]
Thery, Julien [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Orbach, Daniel [Auteur]
Institut Curie [Paris]
Dubray-Longeras, Pascale [Auteur]
Centre Jean Perrin [Clermont-Ferrand] [UNICANCER/CJP]
Verret, Benjamin [Auteur]
Institut Gustave Roussy [IGR]
Bertucci, François [Auteur]
Institut Paoli-Calmettes [IPC]
Guillemet, Cécile [Auteur]
Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen [CLCC Henri Becquerel]
Laroche, Lucie [Auteur]
Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen [CLCC Henri Becquerel]
Dufresne, Armelle [Auteur]
Centre Léon Bérard [Lyon]
Blay, Jean-Yves [Auteur]
Centre Léon Bérard [Lyon]
Le Cesne, Axel [Auteur]
Institut Gustave Roussy [IGR]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Bonvalot, Sylvie [Auteur]
Institut Curie [Paris]
Le Deley, Marie-Cécile [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Italiano, Antoine [Auteur]
Institut Bergonié [Bordeaux]
Tlemsani, Camille [Auteur]
Hôpital Cochin [AP-HP]
Pannier, Diane [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Leguillette, Clémence [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Kurtz, Jean-Emmanuel [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Toulmonde, Maud [Auteur]
Institut Bergonié [Bordeaux]
Thery, Julien [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Orbach, Daniel [Auteur]
Institut Curie [Paris]
Dubray-Longeras, Pascale [Auteur]
Centre Jean Perrin [Clermont-Ferrand] [UNICANCER/CJP]
Verret, Benjamin [Auteur]
Institut Gustave Roussy [IGR]
Bertucci, François [Auteur]
Institut Paoli-Calmettes [IPC]
Guillemet, Cécile [Auteur]
Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen [CLCC Henri Becquerel]
Laroche, Lucie [Auteur]
Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen [CLCC Henri Becquerel]
Dufresne, Armelle [Auteur]
Centre Léon Bérard [Lyon]
Blay, Jean-Yves [Auteur]
Centre Léon Bérard [Lyon]
Le Cesne, Axel [Auteur]
Institut Gustave Roussy [IGR]
Journal title :
International Journal of Cancer
Abbreviated title :
Int J Cancer
Publication date :
2023-03-09
ISSN :
1097-0215
English keyword(s) :
depression
Desmoid-type fibromatosis
outcome
pain
quality of life
Desmoid-type fibromatosis
outcome
pain
quality of life
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The aim of this study is to evaluate the prevalence, determinants and prognostic value of pain at diagnosis in patients with desmoid-type fibromatosis (DF). We selected patients from the ALTITUDES cohort (NCT02867033), ...
Show more >The aim of this study is to evaluate the prevalence, determinants and prognostic value of pain at diagnosis in patients with desmoid-type fibromatosis (DF). We selected patients from the ALTITUDES cohort (NCT02867033), managed by surgery, active surveillance or systemic treatments, with pain assessment at diagnosis. Patients were invited to fill QLQ-C30 questionnaire and Hospital Anxiety Depression Scale. Determinants were identified using logistic models. Prognostic value on event-free survival (EFS) was evaluated using the Cox model. Overall, 382 patients were included in the current study (median age: 40.2 years; 117 men). The prevalence of pain was 36%, without significant difference according to first-line treatment (P =.18). In the multivariate analysis, pain was significantly associated with tumor size >50 mm (P =.013) and tumor site (P <.001); pain was more frequent in the neck and shoulder locations (odds ratio: 3.05 [1.27-7.29]). Pain at baseline was significantly associated with poor quality of life (P <.001), depression (P =.02), lower performance status (P =.03) and functional impairment (P =.001); we also observed a nonsignificant association with anxiety (P =.10). In the univariate analysis, baseline pain was associated with poor EFS; the 3-year EFS was 54% in patients with pain compared to 72% in those without pain. After adjustment for sex, age, size and line of treatment, pain was still associated with poor EFS (hazard ratio: 1.82 [1.23-2.68], P =.003). One third of recently diagnosed patients with DF experienced pain, especially those with larger tumors and neck/shoulder locations. Pain was associated with unfavorable EFS after adjustment for the confounders.Show less >
Show more >The aim of this study is to evaluate the prevalence, determinants and prognostic value of pain at diagnosis in patients with desmoid-type fibromatosis (DF). We selected patients from the ALTITUDES cohort (NCT02867033), managed by surgery, active surveillance or systemic treatments, with pain assessment at diagnosis. Patients were invited to fill QLQ-C30 questionnaire and Hospital Anxiety Depression Scale. Determinants were identified using logistic models. Prognostic value on event-free survival (EFS) was evaluated using the Cox model. Overall, 382 patients were included in the current study (median age: 40.2 years; 117 men). The prevalence of pain was 36%, without significant difference according to first-line treatment (P =.18). In the multivariate analysis, pain was significantly associated with tumor size >50 mm (P =.013) and tumor site (P <.001); pain was more frequent in the neck and shoulder locations (odds ratio: 3.05 [1.27-7.29]). Pain at baseline was significantly associated with poor quality of life (P <.001), depression (P =.02), lower performance status (P =.03) and functional impairment (P =.001); we also observed a nonsignificant association with anxiety (P =.10). In the univariate analysis, baseline pain was associated with poor EFS; the 3-year EFS was 54% in patients with pain compared to 72% in those without pain. After adjustment for sex, age, size and line of treatment, pain was still associated with poor EFS (hazard ratio: 1.82 [1.23-2.68], P =.003). One third of recently diagnosed patients with DF experienced pain, especially those with larger tumors and neck/shoulder locations. Pain was associated with unfavorable EFS after adjustment for the confounders.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Submission date :
2023-11-15T02:22:08Z
2024-03-29T13:41:26Z
2024-03-29T13:41:26Z
Files
- Intl Journal of Cancer - 2023 - Penel - Pain in desmoid‐type fibromatosis Prevalence determinants and prognosis value.pdf
- Non spécifié
- Open access
- Access the document
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States