Titre :

Adverse Maternal and Infant Outcomes in Women With Chronic Hypertension in France (2010-2018): The Nationwide CONCEPTION Study.

Auteur(s) :

Lailler, Grégory [Auteur]
Université Paris-Est [UPE]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Grave, Clémence [Auteur]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Gabet, Amélie [Auteur]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Regnault, Nolwenn [Auteur]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Deneux-Tharaux, Catherine [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Université Paris Cité [UPCité]
Kretz, Sandrine [Auteur]
Centre de Diagnostic et de Thérapeutique, Hôpital de l’Hôtel-Dieu [Paris]
Mounier-Vehier, Claire [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Institut Coeur Poumon [CHU Lille]
Tsatsaris, Vassilis [Auteur]
Hôpital Cochin [AP-HP]
Université Paris Cité [UPCité]
Plu-Bureau, Geneviève [Auteur]
Hôpital Cochin [AP-HP]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Université Paris Cité [UPCité]
Blacher, Jacques [Auteur]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
Université Paris Cité [UPCité]
Olié, Valérie [Auteur]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]

Titre de la revue :

Journal of the American Heart Association

Nom court de la revue :

J Am Heart Assoc

Pagination :

e027266

Date de publication :

2023-03-03

ISSN :

2047-9980

Mot(s)-clé(s) en anglais :

antihypertensive agents
blood pressure
epidemiology
hypertension
pregnancy complication

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background It has been suggested that chronic hypertension is a risk factor for negative maternal and fetal outcomes during pregnancy and postpartum. We aimed to estimate the association of chronic hypertension on adverse ...
Lire la suite >Background It has been suggested that chronic hypertension is a risk factor for negative maternal and fetal outcomes during pregnancy and postpartum. We aimed to estimate the association of chronic hypertension on adverse maternal and infant outcomes and assess the impact of antihypertensive treatment and these outcomes. Methods and Results Using data from the French national health data system, we identified and included in the CONCEPTION cohort all women in France who delivered their first child between 2010 and 2018. Chronic hypertension before pregnancy was identified through antihypertensive medication purchases and by diagnosis during hospitalization. We assessed the incidence risk ratios (IRRs) of maternofetal outcomes using Poisson models. A total of 2 822 616 women were included, and 42 349 (1.5%) had chronic hypertension and 22 816 were treated during pregnancy. In Poisson models, the adjusted IRR (95% CI) of maternofetal outcomes for women with hypertension were as follows: 1.76 (1.54–2.01) for infant death, 1.73 (1.60–1.87) for small gestational age, 2.14 (1.89–2.43) for preterm birth, 4.58 (4.41–4.75) for preeclampsia, 1.33 (1.27–1.39) for cesarean delivery, 1.84 (1.47–2.31) for venous thromboembolism, 2.62 (1.71–4.01) for stroke or acute coronary syndrome, and 3.54 (2.11–5.93) for maternal death postpartum. In women with chronic hypertension, being treated with an antihypertensive drug during pregnancy was associated with a significantly lower risk of obstetric hemorrhage, stroke, and acute coronary syndrome during pregnancy and postpartum. Conclusions Chronic hypertension is a major risk factor of infant and maternal negative outcomes. In women with chronic hypertension, the risk of pregnancy and postpartum cardiovascular events may be decreased by antihypertensive treatment during pregnancy.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T02:24:34Z
2024-04-03T07:05:19Z