Title :

Adverse Maternal and Infant Outcomes in Women With Chronic Hypertension in France (2010-2018): The Nationwide CONCEPTION Study.

Author(s) :

Lailler, Grégory [Auteur]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Université Paris-Est [UPE]
Grave, Clémence [Auteur]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Gabet, Amélie [Auteur]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Regnault, Nolwenn [Auteur]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]
Deneux-Tharaux, Catherine [Auteur]
Université Paris Cité [UPCité]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Kretz, Sandrine [Auteur]
Centre de Diagnostic et de Thérapeutique, Hôpital de l’Hôtel-Dieu [Paris]
Mounier-Vehier, Claire [Auteur]
Institut Coeur Poumon [CHU Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Tsatsaris, Vassilis [Auteur]
Université Paris Cité [UPCité]
Hôpital Cochin [AP-HP]
Plu-Bureau, Geneviève [Auteur]
Université Paris Cité [UPCité]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Hôpital Cochin [AP-HP]
Blacher, Jacques [Auteur]
Université Paris Cité [UPCité]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
Olié, Valérie [Auteur]
Santé publique France - French National Public Health Agency [Saint-Maurice, France]

Journal title :

Journal of the American Heart Association

Abbreviated title :

J Am Heart Assoc

Pages :

e027266

Publication date :

2023-03-03

ISSN :

2047-9980

English keyword(s) :

antihypertensive agents
blood pressure
epidemiology
hypertension
pregnancy complication

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background It has been suggested that chronic hypertension is a risk factor for negative maternal and fetal outcomes during pregnancy and postpartum. We aimed to estimate the association of chronic hypertension on adverse ...
Show more >Background It has been suggested that chronic hypertension is a risk factor for negative maternal and fetal outcomes during pregnancy and postpartum. We aimed to estimate the association of chronic hypertension on adverse maternal and infant outcomes and assess the impact of antihypertensive treatment and these outcomes. Methods and Results Using data from the French national health data system, we identified and included in the CONCEPTION cohort all women in France who delivered their first child between 2010 and 2018. Chronic hypertension before pregnancy was identified through antihypertensive medication purchases and by diagnosis during hospitalization. We assessed the incidence risk ratios (IRRs) of maternofetal outcomes using Poisson models. A total of 2 822 616 women were included, and 42 349 (1.5%) had chronic hypertension and 22 816 were treated during pregnancy. In Poisson models, the adjusted IRR (95% CI) of maternofetal outcomes for women with hypertension were as follows: 1.76 (1.54–2.01) for infant death, 1.73 (1.60–1.87) for small gestational age, 2.14 (1.89–2.43) for preterm birth, 4.58 (4.41–4.75) for preeclampsia, 1.33 (1.27–1.39) for cesarean delivery, 1.84 (1.47–2.31) for venous thromboembolism, 2.62 (1.71–4.01) for stroke or acute coronary syndrome, and 3.54 (2.11–5.93) for maternal death postpartum. In women with chronic hypertension, being treated with an antihypertensive drug during pregnancy was associated with a significantly lower risk of obstetric hemorrhage, stroke, and acute coronary syndrome during pregnancy and postpartum. Conclusions Chronic hypertension is a major risk factor of infant and maternal negative outcomes. In women with chronic hypertension, the risk of pregnancy and postpartum cardiovascular events may be decreased by antihypertensive treatment during pregnancy.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T02:24:34Z
2024-04-03T07:05:19Z