Title :

Senescence induced by UVB in keratinocytes impairs amino acids balance.

Author(s) :

Bauwens, Emilie [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
Parée, Tom [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
Meurant, Sébastien [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
Bouriez, Inès [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
Hannart, Clotilde [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
Wéra, Anne-Catherine [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
Khelfi, Alexis [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
Fattaccioli, Antoine [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
Burteau, Sophie [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
Demazy, Catherine [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
Fransolet, Maude [Auteur]
Namur Research Institute for Life Sciences [NARILIS]
De Schutter, Clémentine [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Martin, Nathalie [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Théry, Julien [Auteur]
CHU Lille - Direction de la recherche et de l’innovation
Decanter, Gauthier [Auteur]
CHU Lille - Direction de la recherche et de l’innovation
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Bury, Marina [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Pluquet, Olivier [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Garmyn, Marjan [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
Debacq-Chainiaux, Florence [Auteur]
Namur Research Institute for Life Sciences [NARILIS]

Journal title :

Journal of Investigative Dermatology

Abbreviated title :

J Invest Dermatol

Publication date :

2022-12-18

ISSN :

1523-1747

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Skin is one of the most exposed organs to external stress. Namely, UV rays are the most harmful stress that could induce important damage leading to skin aging and cancers. At the cellular level, senescence is observed in ...
Show more >Skin is one of the most exposed organs to external stress. Namely, UV rays are the most harmful stress that could induce important damage leading to skin aging and cancers. At the cellular level, senescence is observed in several skin cell types and contributes to skin aging. However, the origin of skin senescent cells is still unclear but is probably related to exposure to stresses. In this work, we developed an in vitro model of UVB-induced premature senescence in normal human epidermal keratinocytes. UVB-induced senescent keratinocytes display a common senescent phenotype resulting in an irreversible cell cycle arrest, an increase in the proportion of senescence-associated β-galactosidase‒positive cells, unrepaired DNA damage, and a long-term DNA damage response activation. Moreover, UVB-induced senescent keratinocytes secrete senescence-associated secretory phenotype factors that influence cutaneous squamous cell carcinoma cell migration. Finally, a global transcriptomic study highlighted that senescent keratinocytes present a decrease in the expression of several amino acid transporters, which is associated with reduced intracellular levels of glycine, alanine, and leucine. Interestingly, the chemical inhibition of the glycine transporter SLC6A9/Glyt1 triggers senescence features.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T02:50:28Z
2023-12-12T13:47:48Z