Titre :

Oropharyngeal samples versus lesion specimens at diagnosis in patients infected with Monkeypox virus in Northern France.

Auteur(s) :

Ouafi, Mahdi [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Regueme, Alexandre [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Alcaraz, Isabelle [Auteur]
Centre Hospitalier Gustave Dron [Tourcoing]
Riviere, Pierre [Auteur]
Bazus, Hélène [Auteur]
Salmon-Rousseau, Arnaud [Auteur]
Cappeliez, Bertrand [Auteur]
Centre Hospitalier Tourcoing
Cartier, Noemie [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Guigon, Aurelie [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Lazrek, Mouna [Auteur]
Pathogenèse virale du diabète de type 1 - ULR 3610
Bocket, Laurence [Auteur]
Pathogenèse virale du diabète de type 1 - ULR 3610
Faure, Emmanuel [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Robineau, Olivier [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Hober, Didier [Auteur]
Pathogenèse virale du diabète de type 1 - ULR 3610
Alidjinou, Enagnon Kazali [Auteur]
Pathogenèse virale du diabète de type 1 - ULR 3610

Titre de la revue :

Journal of Medical Virology

Nom court de la revue :

J Med Virol

Numéro :

95

Date de publication :

2022-11-04

ISSN :

1096-9071

Mot(s)-clé(s) en anglais :

epidemiology
infection
poxvirus
viral excretion
virus classification

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The ongoing outbreak of monkeypox virus (MPXV) is the largest one in historically non-endemic countries. Early reports described atypical epidemiological and clinical presentations. We investigated MPXV DNA detection in ...
Lire la suite >The ongoing outbreak of monkeypox virus (MPXV) is the largest one in historically non-endemic countries. Early reports described atypical epidemiological and clinical presentations. We investigated MPXV DNA detection in oropharyngeal samples (OPS), and compared the viral load to that in lesion samples at diagnosis in patients infected with MPXV. We retrospectively included patients suspected to have monkeypox in Northern France, who underwent a MPXV PCR in the Virology Laboratory, University Hospital of Lille, from May 23 to August 18, 2022. Overall, a total of 228 patients (376 samples) were included. A positive result in at least one sample was found in 138 patients (60.5%). We compared PCR results between OPS and lesion samples (i.e., cutaneous or anal/rectal samples) in patients with both samples. A positive result in OPS was observed in 54 out of 60 patients (90%). The viral load in OPS (median Ct value = 29.5; interquartile range [IQR] = 24.7−34) was significantly lower than that in lesion samples (median Ct value = 17.8; IQR = 16.3 and 19.7) (p < 0.0001). This report shows that pharyngeal sampling does not bring additional information for the initial diagnosis in patients presenting with typical lesions.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Laboratoire de virologie - ULR 3610
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T03:04:07Z
2024-04-26T13:18:53Z