Title :

Low-dose aspirin to prevent preeclampsia and growth restriction in nulliparous women identified by uterine artery Doppler as at high risk of preeclampsia: A double blinded randomized placebo-controlled trial.

Author(s) :

Diguisto, Caroline [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Service de Gynécologie-Obstétrique [CHRU Tours]
Université de Tours [UT]
Le Gouge, Amélie [Auteur]
Centre d’Investigation Clinique [Tours] CIC 1415 [CIC ]
Marchand, Marie-Sara [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Megier, Pascal [Auteur]
Centre Hospitalier Régional d'Orléans [CHRO]
Ville, Yves [Auteur]
Université Paris Cité [UPCité]
Hôpital Necker - Enfants Malades [AP-HP]
Haddad, Georges [Auteur]
Winer, Norbert [Auteur]

Arthuis, Chloé [Auteur]

Doret, Muriel [Auteur]
Service de Gynécologie et Obstétrique [Hôpital de la Croix-Rousse - HCL]
Debarge, Veronique [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Flandrin, Anaig [Auteur]
CHU Montpellier = Montpellier University Hospital
Delmas, Hélène Laurichesse [Auteur]
Service de Gynécologie [CHU Clermont-Ferrand]
Gallot, Denis [Auteur]
Service de Gynécologie [CHU Clermont-Ferrand]
Mares, Pierre [Auteur]
Hôpital Universitaire Carémeau [Nîmes] [CHU Nîmes]
Université de Montpellier [UM]
Vayssiere, Christophe [Auteur]
Equipe SPHERE (CERPOP)
Service Obstétrique [CHU Toulouse]
Sentilhes, Loic [Auteur]

Cheve, Marie-Thérèse [Auteur]
Centre Hospitalier Le Mans (CH Le Mans)
Paumier, Anne [Auteur]
Durin, Luc [Auteur]
Elsan Polyclinique du Parc - Caen
Schaub, Bruno [Auteur]
Maison de la Femme de la Mère et de l'Enfant [CHU de la Martinique] [MFME [Fort de France]]
Equy, Véronique [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Giraudeau, Bruno [Auteur]
Centre d’Investigation Clinique [Tours] CIC 1415 [CIC ]
Université de Tours [UT]
Perrotin, Franck [Auteur]
Service de Gynécologie-Obstétrique [CHRU Tours]
Université de Tours [UT]

Journal title :

PLoS ONE

Abbreviated title :

PLoS One

Volume number :

17

Pages :

e0275129

Publication date :

2022-10-26

ISSN :

1932-6203

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Introduction This trial evaluates whether daily low-dose aspirin initiated before 16 weeks of gestation can reduce preeclampsia and fetal growth restriction in nulliparous women identified by first-trimester uterine artery ...
Show more >Introduction This trial evaluates whether daily low-dose aspirin initiated before 16 weeks of gestation can reduce preeclampsia and fetal growth restriction in nulliparous women identified by first-trimester uterine artery Dopplers as at high risk of preeclampsia. Methods This randomized, blinded, placebo-controlled, parallel-group trial took place in 17 French obstetric departments providing antenatal care. Pregnant nulliparous women aged ≥ 18 years with a singleton pregnancy at a gestational age < 16 weeks of gestation with a lowest pulsatility index ≥ 1.7 or a bilateral protodiastolic notching for both uterine arteries on an ultrasound performed between 11+0 and 13+6 weeks by a certified sonographer were randomized at a 1:1 ratio to 160 mg of low-dose aspirin or to placebo to be taken daily from inclusion to their 34th week of gestation. The main outcome was preeclampsia or a birthweight ≤ 5th percentile. Other outcomes included preeclampsia, severe preeclampsia, preterm preeclampsia, preterm delivery before 34 weeks, mode of delivery, type of anesthesia, birthweight ≤ 5th percentile and perinatal death. Results The trial was interrupted due to recruiting difficulties. Between June 2012 and June 2016, 1104 women were randomized, two withdrew consent, and two had terminations of pregnancies. Preeclampsia or a birthweight ≤ 5th percentile occurred in 88 (16.0%) women in the low-dose aspirin group and in 79 (14.4%) in the placebo group (proportion difference 1.6 [-2.6; 5.9] p = 0.45). The two groups did not differ significantly for the secondary outcomes. Conclusion Low-dose aspirin was not associated with a lower rate of either preeclampsia or birthweight ≤ 5th percentile in women identified by their first-trimester uterine artery Doppler as at high risk of preeclampsia. Trial registration ( NCT0172946 ).Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T03:09:23Z
2024-01-18T08:13:38Z