Long-Term Functional Outcomes of an Anorectal ...
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Article dans une revue scientifique: Article original
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Title :
Long-Term Functional Outcomes of an Anorectal Malformation French National Cohort
Author(s) :
Schmitt, Françoise [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Scalabre, Aurélien [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Mure, Pierre Y. [Auteur]
Borrione, Claude [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Lemelle, Jean-Louis [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Sharma, Dyuti [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
De Napoli, Stéphan [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Irtan, Sabine [Auteur]
CHU Trousseau [APHP]
Levard, Guillaume [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Becmeur, François [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Buisson, Philippe [Auteur]
CHU Amiens-Picardie
Fourcade, Laurent [Auteur]
CHU Limoges
Arnaud, Alexis [Auteur]
Centre Hospitalier Universitaire [Rennes]
De Vries, Philine [Auteur]
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Branchereau, Sophie [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Garignon, Cynthia [Auteur]
Sauvat, Frédérique [Auteur]
Centre Hospitalier Universitaire de La Réunion [CHU La Réunion]
Kalfa, Nicolas [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Lardy, Hubert [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Jochault-Ritz, Sandy [Auteur]
CH Colmar
Sapin, Emmanuel [Auteur]
Coridon, Hélène [Auteur]
Margaryan, Marc [Auteur]
Centre Hospitalier Le Mans (CH Le Mans)
Pouzac, Myriam [Auteur]
Centre Hospitalier Régional d'Orléans [CHRO]
Carfagna, Luana [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Polimerol, Marie Laurence [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Varlet, François [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Sarnacki, Sabine [Auteur]
Cretolle, Célia [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Podevin, Guillaume [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Scalabre, Aurélien [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Mure, Pierre Y. [Auteur]
Borrione, Claude [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Lemelle, Jean-Louis [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Sharma, Dyuti [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
De Napoli, Stéphan [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Irtan, Sabine [Auteur]
CHU Trousseau [APHP]
Levard, Guillaume [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Becmeur, François [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Buisson, Philippe [Auteur]
CHU Amiens-Picardie
Fourcade, Laurent [Auteur]
CHU Limoges
Arnaud, Alexis [Auteur]
Centre Hospitalier Universitaire [Rennes]
De Vries, Philine [Auteur]
Centre Hospitalier Régional Universitaire de Brest [CHRU Brest]
Branchereau, Sophie [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Garignon, Cynthia [Auteur]
Sauvat, Frédérique [Auteur]
Centre Hospitalier Universitaire de La Réunion [CHU La Réunion]
Kalfa, Nicolas [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Lardy, Hubert [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Jochault-Ritz, Sandy [Auteur]
CH Colmar
Sapin, Emmanuel [Auteur]
Coridon, Hélène [Auteur]
Margaryan, Marc [Auteur]
Centre Hospitalier Le Mans (CH Le Mans)
Pouzac, Myriam [Auteur]
Centre Hospitalier Régional d'Orléans [CHRO]
Carfagna, Luana [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Polimerol, Marie Laurence [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Varlet, François [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Sarnacki, Sabine [Auteur]
Cretolle, Célia [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Podevin, Guillaume [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Journal title :
Journal of Pediatric Gastroenterology and Nutrition
Abbreviated title :
J. Pediatr. Gastroenterol. Nutr.
Volume number :
74
Pages :
-
Publication date :
2022-06-15
ISSN :
0277-2116
English keyword(s) :
age group assessment
clinical functioning
social integration
clinical functioning
social integration
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Objectives:
The present study aimed to assess long-term functional outcomes of children with anorectal malformations (ARMs) across a network of expert centers in France.
Methods:
Retrospective cross-sectional study ...
Show more >Objectives: The present study aimed to assess long-term functional outcomes of children with anorectal malformations (ARMs) across a network of expert centers in France. Methods: Retrospective cross-sectional study of patients ages 6–30 years that had been surgically treated for ARM. Patient and ARM characteristics (eg, level, surgical approach) and functional outcomes were assessed in the different age groups. Results: Among 367 patients, there were 155 females (42.2%) and 212 males (57.8%), 188 (51.2%) cases with, and 179 (48.8%) higher forms without, perineal fistula. Univariate and multivariate statistical analyses with logistic regression showed correlation between the level of the rectal blind pouch and voluntary bowel movements (odds ratio [OR] = 1.84 [1.31–2.57], P < 0.001), or soiling (OR = 1.72 [1.31–2.25], P < 0.001), which was also associated with the inability to discriminate between stool and gas (OR = 2.45 [1.28–4.67], P = 0.007) and the presence of constipation (OR = 2.97 [1.74–5.08], P < 0.001). Risk factors for constipation were sacral abnormalities [OR = 2.26 [1.23–4.25], P = 0.01) and surgical procedures without an abdominal approach (OR = 2.98 [1.29–6.87], P = 0.01). Only the holding of voluntary bowel movements and soiling rates improved with age. Conclusion: This cross-sectional study confirms a strong association between anatomical status and functional outcomes in patients surgically treated for ARM. It specifically highlights the need for long-term follow-up of all patients to help them with supportive care.Show less >
Show more >Objectives: The present study aimed to assess long-term functional outcomes of children with anorectal malformations (ARMs) across a network of expert centers in France. Methods: Retrospective cross-sectional study of patients ages 6–30 years that had been surgically treated for ARM. Patient and ARM characteristics (eg, level, surgical approach) and functional outcomes were assessed in the different age groups. Results: Among 367 patients, there were 155 females (42.2%) and 212 males (57.8%), 188 (51.2%) cases with, and 179 (48.8%) higher forms without, perineal fistula. Univariate and multivariate statistical analyses with logistic regression showed correlation between the level of the rectal blind pouch and voluntary bowel movements (odds ratio [OR] = 1.84 [1.31–2.57], P < 0.001), or soiling (OR = 1.72 [1.31–2.25], P < 0.001), which was also associated with the inability to discriminate between stool and gas (OR = 2.45 [1.28–4.67], P = 0.007) and the presence of constipation (OR = 2.97 [1.74–5.08], P < 0.001). Risk factors for constipation were sacral abnormalities [OR = 2.26 [1.23–4.25], P = 0.01) and surgical procedures without an abdominal approach (OR = 2.98 [1.29–6.87], P = 0.01). Only the holding of voluntary bowel movements and soiling rates improved with age. Conclusion: This cross-sectional study confirms a strong association between anatomical status and functional outcomes in patients surgically treated for ARM. It specifically highlights the need for long-term follow-up of all patients to help them with supportive care.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Submission date :
2023-11-15T03:41:27Z
2024-05-13T12:40:56Z
2024-05-13T12:40:56Z
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