Titre :

Subchondral involvement in osteonecrosis of the femoral head: insight on local composition, microstructure and vascularization.

Auteur(s) :

Pascart, Tristan [Auteur]
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Falgayrac, Guillaume [Auteur]
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Cortet, Bernard [Auteur]
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Paccou, Julien [Auteur]
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Coursier, Raphaël [Auteur]
Hôpital Saint Vincent de Paul de Lille
Putman, Sophie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Quinchon, J. F. [Auteur]
Bertheaume, Nicolas [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Delattre, Jérôme [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Marchandise, Pierre [Auteur]
Unité de Taphonomie Médico-Légale & d’Anatomie (UTMLA) - ULR 7367
Unité de Taphonomie Médico-Légale (UTML) - ULR 7367
Cultot, A. [Auteur]
Norberciak, L. [Auteur]
Kerckhofs, G. [Auteur]
Budzik, Jean-Francois [Auteur]
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490

Titre de la revue :

Osteoarthritis and Cartilage

Nom court de la revue :

Osteoarthritis Cartilage

Numéro :

30

Pagination :

1103-1115

Date de publication :

2022-05-17

ISSN :

1522-9653

Mot(s)-clé(s) en anglais :

Osteonecrosis femoral head
Avascular necrosis
Raman spectroscopy
Contrast -enhanced computed&nbsp
microtomography
Bone marrow adiposity
Dynamic-contrast enhanced MRI

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Objective To determine changes of subchondral bone composition, micro-structure, bone marrow adiposity and micro-vascular perfusion in end-stage osteonecrosis of the femoral head (ONFH) compared to osteoarthritis (OA) ...
Lire la suite >Objective To determine changes of subchondral bone composition, micro-structure, bone marrow adiposity and micro-vascular perfusion in end-stage osteonecrosis of the femoral head (ONFH) compared to osteoarthritis (OA) using a combined in vivo and ex vivo approach. Design Male patients up to 70 years old referred for total hip replacement surgery for end-stage ONFH were included (n = 14). Fifteen patients with OA were controls. Pre-operative MRI was used to assess bone perfusion (dynamic contrast-enhanced (DCE) sequences) and marrow fat content (chemical shift imaging). Three distinct zones of femoral head subchondral bone – necrotic, sclerotic, distant – were compared between groups. After surgery, plugs were sampled in these zones and Raman spectroscopy was applied to characterize bone mineral and organic components (old and newly-formed), and contrast-enhanced micro-computed tomography (CE-μCT) to determine bone micro-structural parameters and volume of bone marrow adipocytes, using conventional 2D histology as a reference. Results In the necrotic zone of ONFH patients compared to OA patients: 1) the subchondral plate did not exhibit significant changes in composition nor structure; 2) the volume fraction of subchondral trabecular bone was significantly lower; 3) type-B carbonate substitution was less pronounced, 4) collagen maturity was more pronounced; and 5) bone marrow adipocytes were significantly depleted. The sclerotic zone from the ONFH group showed greater trabecular thickness, and higher DCE-MRI AUC and Ktrans. Volume fraction of subchondral bone, trabecular number, and Kep were significantly lower in the distant zone of the ONFH group. Conclusions This study demonstrated alterations of subchondral bone microstructure, composition, perfusion and/or adipose content in all zones of the femoral head.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
• Unité de Taphonomie Médico-Légale & d’Anatomie (UTMLA) - ULR 7367

Date de dépôt :

2023-11-15T04:09:58Z
2024-04-22T10:05:05Z