Subchondral involvement in osteonecrosis ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Subchondral involvement in osteonecrosis of the femoral head: insight on local composition, microstructure and vascularization.
Author(s) :
Pascart, Tristan [Auteur]
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Falgayrac, Guillaume [Auteur]
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Cortet, Bernard [Auteur]
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Paccou, Julien [Auteur]
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Coursier, Raphaël [Auteur]
Hôpital Saint Vincent de Paul de Lille
Putman, Sophie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Quinchon, J. F. [Auteur]
Bertheaume, Nicolas [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Delattre, Jérôme [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Marchandise, Pierre [Auteur]
Unité de Taphonomie Médico-Légale & d’Anatomie (UTMLA) - ULR 7367
Unité de Taphonomie Médico-Légale (UTML) - ULR 7367
Cultot, A. [Auteur]
Norberciak, L. [Auteur]
Kerckhofs, G. [Auteur]
Budzik, Jean-Francois [Auteur]
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490

Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Falgayrac, Guillaume [Auteur]

Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Cortet, Bernard [Auteur]

Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Paccou, Julien [Auteur]

Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Coursier, Raphaël [Auteur]
Hôpital Saint Vincent de Paul de Lille
Putman, Sophie [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Quinchon, J. F. [Auteur]
Bertheaume, Nicolas [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Delattre, Jérôme [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Marchandise, Pierre [Auteur]
Unité de Taphonomie Médico-Légale & d’Anatomie (UTMLA) - ULR 7367
Unité de Taphonomie Médico-Légale (UTML) - ULR 7367
Cultot, A. [Auteur]
Norberciak, L. [Auteur]
Kerckhofs, G. [Auteur]
Budzik, Jean-Francois [Auteur]

Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Journal title :
Osteoarthritis and Cartilage
Abbreviated title :
Osteoarthritis Cartilage
Volume number :
30
Pages :
1103-1115
Publication date :
2022-05-17
ISSN :
1522-9653
English keyword(s) :
Osteonecrosis femoral head
Avascular necrosis
Raman spectroscopy
Contrast -enhanced computed 
microtomography
Bone marrow adiposity
Dynamic-contrast enhanced MRI
Avascular necrosis
Raman spectroscopy
Contrast -enhanced computed 
microtomography
Bone marrow adiposity
Dynamic-contrast enhanced MRI
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Objective
To determine changes of subchondral bone composition, micro-structure, bone marrow adiposity and micro-vascular perfusion in end-stage osteonecrosis of the femoral head (ONFH) compared to osteoarthritis (OA) ...
Show more >Objective To determine changes of subchondral bone composition, micro-structure, bone marrow adiposity and micro-vascular perfusion in end-stage osteonecrosis of the femoral head (ONFH) compared to osteoarthritis (OA) using a combined in vivo and ex vivo approach. Design Male patients up to 70 years old referred for total hip replacement surgery for end-stage ONFH were included (n = 14). Fifteen patients with OA were controls. Pre-operative MRI was used to assess bone perfusion (dynamic contrast-enhanced (DCE) sequences) and marrow fat content (chemical shift imaging). Three distinct zones of femoral head subchondral bone – necrotic, sclerotic, distant – were compared between groups. After surgery, plugs were sampled in these zones and Raman spectroscopy was applied to characterize bone mineral and organic components (old and newly-formed), and contrast-enhanced micro-computed tomography (CE-μCT) to determine bone micro-structural parameters and volume of bone marrow adipocytes, using conventional 2D histology as a reference. Results In the necrotic zone of ONFH patients compared to OA patients: 1) the subchondral plate did not exhibit significant changes in composition nor structure; 2) the volume fraction of subchondral trabecular bone was significantly lower; 3) type-B carbonate substitution was less pronounced, 4) collagen maturity was more pronounced; and 5) bone marrow adipocytes were significantly depleted. The sclerotic zone from the ONFH group showed greater trabecular thickness, and higher DCE-MRI AUC and Ktrans. Volume fraction of subchondral bone, trabecular number, and Kep were significantly lower in the distant zone of the ONFH group. Conclusions This study demonstrated alterations of subchondral bone microstructure, composition, perfusion and/or adipose content in all zones of the femoral head.Show less >
Show more >Objective To determine changes of subchondral bone composition, micro-structure, bone marrow adiposity and micro-vascular perfusion in end-stage osteonecrosis of the femoral head (ONFH) compared to osteoarthritis (OA) using a combined in vivo and ex vivo approach. Design Male patients up to 70 years old referred for total hip replacement surgery for end-stage ONFH were included (n = 14). Fifteen patients with OA were controls. Pre-operative MRI was used to assess bone perfusion (dynamic contrast-enhanced (DCE) sequences) and marrow fat content (chemical shift imaging). Three distinct zones of femoral head subchondral bone – necrotic, sclerotic, distant – were compared between groups. After surgery, plugs were sampled in these zones and Raman spectroscopy was applied to characterize bone mineral and organic components (old and newly-formed), and contrast-enhanced micro-computed tomography (CE-μCT) to determine bone micro-structural parameters and volume of bone marrow adipocytes, using conventional 2D histology as a reference. Results In the necrotic zone of ONFH patients compared to OA patients: 1) the subchondral plate did not exhibit significant changes in composition nor structure; 2) the volume fraction of subchondral trabecular bone was significantly lower; 3) type-B carbonate substitution was less pronounced, 4) collagen maturity was more pronounced; and 5) bone marrow adipocytes were significantly depleted. The sclerotic zone from the ONFH group showed greater trabecular thickness, and higher DCE-MRI AUC and Ktrans. Volume fraction of subchondral bone, trabecular number, and Kep were significantly lower in the distant zone of the ONFH group. Conclusions This study demonstrated alterations of subchondral bone microstructure, composition, perfusion and/or adipose content in all zones of the femoral head.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Submission date :
2023-11-15T04:09:58Z
2024-04-22T10:05:05Z
2024-04-22T10:05:05Z