Titre :

Associations between fetal heart rate variability and umbilical cord occlusions-induced neural injury: An experimental study in a fetal sheep model.

Auteur(s) :

Ghesquière, Louise [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Perbet, Romain [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lacan, Laure [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Ould Hamoud, Yasmine [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Stichelbout, Morgane [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Sharma, Dyuti [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Nguyen The Tich, Sylvie [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Storme, Laurent [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Debarge, Veronique [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
De Jonckheere, Julien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Garabedian, Charles [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Titre de la revue :

Acta Obstetricia et Gynecologica Scandinavica

Nom court de la revue :

Acta Obstet Gynecol Scand

Numéro :

101

Pagination :

758-770

Date de publication :

2022-05-05

ISSN :

1600-0412

Mot(s)-clé(s) en anglais :

autonomic nervous system
fetal heart rate
heart rate variability
intrapartum hypoxic-ischemia
neural injury
umbilical cord compression

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Introduction This study evaluated the association between fetal heart rate variability (HRV) and the occurrence of hypoxic–ischemic encephalopathy in a fetal sheep model. Material and methods The experimental protocol ...
Lire la suite >Introduction This study evaluated the association between fetal heart rate variability (HRV) and the occurrence of hypoxic–ischemic encephalopathy in a fetal sheep model. Material and methods The experimental protocol created a hypoxic condition with repeated cord occlusions in three phases (A, B, C) to achieve acidosis to pH <7.00. Hemodynamic, gasometric and HRV parameters were analyzed during the protocol, and the fetal brain, brainstem and spinal cord were assessed histopathologically 48 h later. Associations between the various parameters and neural injury were compared between phases A, B and C using Spearman's rho test. Results Acute anoxic–ischemic brain lesions in all regions was present in 7/9 fetuses, and specific neural injury was observed in 3/9 fetuses. The number of brainstem lesions correlated significantly and inversely with the HRV fetal stress index (r = −0.784; p = 0.021) in phase C and with HRV long-term variability (r = −0.677; p = 0.045) and short-term variability (r = −0.837; p = 0.005) in phase B. The number of neurological lesions did not correlate significantly with other markers of HRV. Conclusions Neural injury caused by severe hypoxia was associated with HRV changes; in particular, brainstem damage was associated with changes in fetal-specific HRV markers.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T04:14:23Z
2024-04-08T08:31:22Z