Titre :

Persistent symptoms after the first wave of COVID-19 in relation to SARS-CoV-2 serology and experience of acute symptoms: A nested survey in a population-based cohort.

Auteur(s) :

Robineau, Olivier [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Wiernik, Emmanuel [Auteur]
Cohortes épidémiologiques en population [CONSTANCES]
Lemogne, Cédric [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
De Lamballerie, Xavier [Auteur]
Institut de Recherche pour le Développement [IRD]
Unité des Virus Emergents [UVE]
Ninove, Laetitia [Auteur]
Unité des Virus Emergents [UVE]
Blanché, Hélène [Auteur]
Fondation Jean Dausset CEPH
Deleuze, Jean-François [Auteur]
Fondation Jean Dausset CEPH
Ribet, Céline [Auteur]
Cohortes épidémiologiques en population [CONSTANCES]
Kab, Sofiane [Auteur]
Cohortes épidémiologiques en population [CONSTANCES]
Goldberg, Marcel [Auteur]
Cohortes épidémiologiques en population [CONSTANCES]
Severi, Gianluca [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Touvier, Mathilde [Auteur]
Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle [EREN [CRESS - U1153 / UMR_A 1125]]
Zins, Marie [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Carrat, Fabrice [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]

Titre de la revue :

The Lancet Regional Health - Europe

Nom court de la revue :

Lancet Reg Health Eur

Numéro :

17

Pagination :

100363

Date de publication :

2022-04-26

ISSN :

2666-7762

Mot(s)-clé(s) en anglais :

COVID-19
Long-covid
Post-infectious symptoms
Persistent symptoms
Populationbased study
Constances
Post-covid condition

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Many patients report persistent symptoms after COVID-19. Our aim was to determine whether some of these symptoms were more associated with past SARS-CoV-2 infection compared to other conditions. Methods This ...
Lire la suite >Background Many patients report persistent symptoms after COVID-19. Our aim was to determine whether some of these symptoms were more associated with past SARS-CoV-2 infection compared to other conditions. Methods This prospective survey was nested in CONSTANCES, a randomly selected French population-based cohort, started in 2012. All participants being followed-up by internet completed 2 questionnaires during the first wave of the pandemic focusing on the acute symptoms of their COVID-19-like illness. Serological tests for SARS-CoV-2 were then performed (May-Nov 2020). Between December 2020 and January 2021, participants completed a third questionnaire about symptoms that had lasted more than 2 months. Participants were classified into four groups according to both European Center for Diseases Control (ECDC) criteria for COVID-19 (ECDC+ or ECDC-) and serological SARS-CoV-2 test results (Sero+ or Sero-). To compare the risk of each persistent symptom among the groups, logistic regression models were adjusted for age, sex, educational level, comorbidities, and the number of acute symptoms declared during the first wave of the epidemic. A mediation analysis was performed to estimate the direct effect of the infection on persistent symptoms and its indirect effect via the initial clinical presentation. Findings The analysis was performed in 25,910 participants. There was a higher risk of persistent dysgeusia/anosmia, dyspnea and asthenia in the ECDC+/Sero+ group than in the ECDC+/Sero- group (OR: 6.83 [4.47–10.42], 1.69 [1.07–2.6] and 1.48 [1.05–2.07], respectively). Abdominal pain, sensory symptoms or sleep disorders were at lower risk in the ECDC+/Sero+ group than in the ECDC+/Sero- group (0.51 [0.24–0.96], 0.40 [0.16–0.85], and 0.69 [0.49–0.95], respectively). The mediation analysis revealed that the association of the serological test results with each symptom was mainly mediated by ECDC symptoms (proportion mediated range 50–107%). Conclusion A greater risk of persistent dysgeusia/anosmia, dyspnea and asthenia was observed in SARS-CoV-2 infected people. The initial clinical presentation substantially drives the association of positive serological test results with persistent symptoms.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T04:17:51Z
2024-05-13T07:03:36Z