Title :

Cardiac involvement in pediatric hemolytic uremic syndrome.

Author(s) :

Tanné, Corentin [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Service de néphrologie, rhumatologie et dermatologie pédiatriques [Hôpital Femme Mère Enfant, HCL]
Javouhey, Etienne [Auteur]
Hôpital Femme Mère Enfant [CHU - HCL] [HFME]
Université Claude Bernard Lyon 1 [UCBL]
Boyer, Olivia [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Imagine - Institut des maladies génétiques [IMAGINE - U1163]
Recher, Morgan [Auteur]
Hôpital Jeanne de Flandre [Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Allain-Launay, Emma [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Monet-Didailler, Catherine [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU de Bordeaux]
Centre Hospitalier de la Côte Basque [CHCB]
Rouset-Rouvière, Caroline [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Ryckewaert, Amélie [Auteur]
Service de chirurgie pédiatrique [Rennes] = Paediatric / Pediatric surgery [Rennes]
Nobili, François [Auteur]
Service de pédiatrie [CHRU Besançon]
Gindre, Francine Arfbez [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Rambaud, Jérôme [Auteur]
CHU Trousseau [APHP]
Duncan, Anita [Auteur]
Service de néphrologie, rhumatologie et dermatologie pédiatriques [Hôpital Femme Mère Enfant, HCL]
Berthiller, Julien [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Bacchetta, Justine [Auteur]
Service de néphrologie, rhumatologie et dermatologie pédiatriques [Hôpital Femme Mère Enfant, HCL]
Université Claude Bernard Lyon 1 [UCBL]
Sellier-Leclerc, Anne-Laure [Auteur]
Service de néphrologie, rhumatologie et dermatologie pédiatriques [Hôpital Femme Mère Enfant, HCL]

Journal title :

Pediatric Nephrology

Abbreviated title :

Pediatr Nephrol

Publication date :

2022-03-16

ISSN :

1432-198X

English keyword(s) :

Hemolytic uremic syndrome
Myocarditis
Myocardial dysfunction
Children
Risk factor

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Cardiac involvement is a known but rare complication of pediatric hemolytic uremic syndrome (HUS). We conducted a nationwide observational, retrospective case–control study describing factors associated with ...
Show more >Background Cardiac involvement is a known but rare complication of pediatric hemolytic uremic syndrome (HUS). We conducted a nationwide observational, retrospective case–control study describing factors associated with the occurrence of myocarditis among HUS patients. Methods Cases were defined as hospitalized children affected by any form of HUS with co-existent myocarditis in 8 French Pediatric Intensive Care Units (PICU) between January 2007 and December 2018. Control subjects were children, consecutively admitted with any form of HUS without coexistent myocarditis, at a single PICU in Lyon, France, during the same time period. Results A total of 20 cases of myocarditis were reported among 8 PICUs, with a mean age of 34.3 ± 31.9 months; 66 controls were identified. There were no differences between the two groups concerning the season and the typical, Shiga toxin-producing Escherichia coli (STEC-HUS), or atypical HUS (aHUS). Maximal leukocyte count was higher in the myocarditis group (29.1 ± 16.3G/L versus 21.0 ± 9.9G/L, p = 0.04). The median time between admission and first cardiac symptoms was of 3 days (range 0–19 days), and 4 patients displayed myocarditis at admission. The fatality rate in the myocarditis group was higher than in the control group (40.0% versus 1.5%, p < 0.001). Thirteen (65%) children from the myocarditis group received platelet transfusion compared to 19 (29%) in the control group (p = 0.03). Conclusion Our study confirms that myocarditis is potentially lethal and identifies higher leukocyte count and platelet transfusion as possible risk factors of myocarditis.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T04:29:12Z
2024-01-12T13:06:47Z
2024-01-12T14:04:43Z