Dual-energy CT lung perfusion characteristics ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Dual-energy CT lung perfusion characteristics in pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease and/or pulmonary capillary hemangiomatosis (PVOD/PCH): preliminary experience in 63 patients.
Auteur(s) :
Lefebvre, Briac [Auteur]
Institut Coeur Poumon [CHU Lille]
Kyheng, MaÉva [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Service de Biostatistiques [CHRU Lille]
Giordano, Jessica [Auteur]
Institut Coeur Poumon [CHU Lille]
Lamblin, Nicolas [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Institut Coeur Poumon [CHU Lille]
300166|||Institut Pasteur de Lille
De Groote, Pascal [Auteur]
Institut Coeur Poumon [CHU Lille]
300166|||Institut Pasteur de Lille
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Fertin, Marie [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
569210|||Institut Coeur Poumon [CHU Lille]
300166|||Institut Pasteur de Lille
Delobelle, Marie [Auteur]
Institut Coeur Poumon [CHU Lille]
Perez, Thierry [Auteur]
Institut Coeur Poumon [CHU Lille]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Faivre, Jean-Baptiste [Auteur]
Institut Coeur Poumon [CHU Lille]
Remy, Jacques [Auteur]
Institut Coeur Poumon [CHU Lille]
Duhamel, Alain [Auteur]
Service de Biostatistiques [CHRU Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Remy, Martine [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Institut Coeur Poumon [CHU Lille]
Institut Coeur Poumon [CHU Lille]
Kyheng, MaÉva [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Service de Biostatistiques [CHRU Lille]
Giordano, Jessica [Auteur]
Institut Coeur Poumon [CHU Lille]
Lamblin, Nicolas [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Institut Coeur Poumon [CHU Lille]
300166|||Institut Pasteur de Lille
De Groote, Pascal [Auteur]
Institut Coeur Poumon [CHU Lille]
300166|||Institut Pasteur de Lille
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Fertin, Marie [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
569210|||Institut Coeur Poumon [CHU Lille]
300166|||Institut Pasteur de Lille
Delobelle, Marie [Auteur]
Institut Coeur Poumon [CHU Lille]
Perez, Thierry [Auteur]
Institut Coeur Poumon [CHU Lille]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Faivre, Jean-Baptiste [Auteur]
Institut Coeur Poumon [CHU Lille]
Remy, Jacques [Auteur]
Institut Coeur Poumon [CHU Lille]
Duhamel, Alain [Auteur]
Service de Biostatistiques [CHRU Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Remy, Martine [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Institut Coeur Poumon [CHU Lille]
Titre de la revue :
European Radiology
Nom court de la revue :
Eur Radiol
Date de publication :
2022-03-15
ISSN :
1432-1084
Mot(s)-clé(s) en anglais :
Humans
Respiratory system abnormalities
Computed tomography
Lung
Perfusion
Respiratory system abnormalities
Computed tomography
Lung
Perfusion
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Background
In the stratification of potential causes of PH, current guidelines recommend performing V/Q lung scintigraphy to screen for CTEPH. The recognition of CTEPH is based on the identification of lung segments or ...
Lire la suite >Background In the stratification of potential causes of PH, current guidelines recommend performing V/Q lung scintigraphy to screen for CTEPH. The recognition of CTEPH is based on the identification of lung segments or sub-segments without perfusion but preserved ventilation. The presence of mismatched perfusion defects has also been described in a small proportion of idiopathic pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease and/or pulmonary capillary hemangiomatosis (PVOD/PCH). Dual-energy CT lung perfusion changes have not been specifically investigated in these two entities. Purpose To compare dual-energy CT (DECT) perfusion characteristics in PAH and PVOD/PCH, with specific interest in PE-type perfusion defects. Materials and methods Sixty-three patients with idiopathic or heritable PAH (group A; n = 51) and PVOD/PCH (group B; n = 12) were investigated with DECT angiography with reconstruction of morphologic and perfusion images. Results The number of patients with abnormal perfusion did not differ between group A (35/51; 68.6%) and group B (6/12; 50%) (p = 0.31) nor did the mean number of segments with abnormal perfusion per patient (group A: 17.9 ± 4.9; group B: 18.3 ± 4.1; p = 0.91). The most frequent finding was the presence of patchy defects in group A (15/35; 42.9%) and a variable association of perfusion abnormalities in group B (4/6; 66.7%). The median percentage of segments with PE-type defects per patient was significantly higher in group B than in group A (p = 0.041). Two types of PE-type defects were depicted in 8 patients (group A: 5/51; 9.8%; group B: 3/12; 25%), superimposed on PH-related lung abnormalities (7/8) or normal lung (1/8). The iodine concentration was significantly lower in patients with abnormal perfusion (p < 0.001) but did not differ between groups. Conclusion Perfusion abnormalities did not differ between the two groups at the exception of a higher median percentage of segments with PE-type defects in patients with PVOD/PCH. Key Points • Patchy perfusion defect was the most frequent pattern in PAH. • A variable association of perfusion abnormalities was seen in PVOD/PCH. • Lobular and PE-type perfusion defects larger than a sub-segment were depicted in both PAH and PVOD/PCH patients.Lire moins >
Lire la suite >Background In the stratification of potential causes of PH, current guidelines recommend performing V/Q lung scintigraphy to screen for CTEPH. The recognition of CTEPH is based on the identification of lung segments or sub-segments without perfusion but preserved ventilation. The presence of mismatched perfusion defects has also been described in a small proportion of idiopathic pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease and/or pulmonary capillary hemangiomatosis (PVOD/PCH). Dual-energy CT lung perfusion changes have not been specifically investigated in these two entities. Purpose To compare dual-energy CT (DECT) perfusion characteristics in PAH and PVOD/PCH, with specific interest in PE-type perfusion defects. Materials and methods Sixty-three patients with idiopathic or heritable PAH (group A; n = 51) and PVOD/PCH (group B; n = 12) were investigated with DECT angiography with reconstruction of morphologic and perfusion images. Results The number of patients with abnormal perfusion did not differ between group A (35/51; 68.6%) and group B (6/12; 50%) (p = 0.31) nor did the mean number of segments with abnormal perfusion per patient (group A: 17.9 ± 4.9; group B: 18.3 ± 4.1; p = 0.91). The most frequent finding was the presence of patchy defects in group A (15/35; 42.9%) and a variable association of perfusion abnormalities in group B (4/6; 66.7%). The median percentage of segments with PE-type defects per patient was significantly higher in group B than in group A (p = 0.041). Two types of PE-type defects were depicted in 8 patients (group A: 5/51; 9.8%; group B: 3/12; 25%), superimposed on PH-related lung abnormalities (7/8) or normal lung (1/8). The iodine concentration was significantly lower in patients with abnormal perfusion (p < 0.001) but did not differ between groups. Conclusion Perfusion abnormalities did not differ between the two groups at the exception of a higher median percentage of segments with PE-type defects in patients with PVOD/PCH. Key Points • Patchy perfusion defect was the most frequent pattern in PAH. • A variable association of perfusion abnormalities was seen in PVOD/PCH. • Lobular and PE-type perfusion defects larger than a sub-segment were depicted in both PAH and PVOD/PCH patients.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
CHU Lille
Date de dépôt :
2023-11-15T04:29:40Z
2024-01-12T14:22:46Z
2024-01-12T14:22:46Z