Titre :

Risk factors for severe neonatal thrombocytopenia in cases of maternal immune thrombocytopenia.

Auteur(s) :

Point, Florian [Auteur]
Département d'obstétrique[Lille]
Terriou, Louis [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Rakza, Thameur [Auteur]
Département d'obstétrique[Lille]
Drumez, Elodie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Alluin, Gauthier [Auteur]
Etablissement Français du Sang Hauts-de-France - Normandie [EFS Hauts-de-France - Normandie]
Garabedian, Charles [Auteur]
Département d'obstétrique[Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Debarge, Veronique [Auteur]
Département d'obstétrique[Lille]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Titre de la revue :

Acta Paediatrica

Nom court de la revue :

Acta Paediatr

Date de publication :

2022-01-17

ISSN :

1651-2227

Mot(s)-clé(s) en anglais :

haemorrhage
immune thrombocytopenia
neonatal thrombocytopenia
platelet
pregnancy

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Aim Maternal immune thrombocytopenia (ITP) may induce neonatal thrombocytopenia (nTP), which carries a risk of neonatal haemorrhagic complications. Some risk factors for nTP have reached consensus such as maternal ...
Lire la suite >Aim Maternal immune thrombocytopenia (ITP) may induce neonatal thrombocytopenia (nTP), which carries a risk of neonatal haemorrhagic complications. Some risk factors for nTP have reached consensus such as maternal splenectomy and previous severe nTP, while others such as maternal platelet count have not. Methods We conducted a retrospective cohort study in a university hospital, including 145 neonates of mothers with ITP. We assessed the risk of severe nTP and bleeding complications. Results Severe nTP in the first 24 h after birth was more common in case of maternal splenectomy (OR = 4.4) and a previous severe nTP (OR = 46.9). Severe nTP at nadir (lowest platelet count during the initial postnatal days) was more frequent in cases of a previous neonate with severe nTP (OR = 42), maternal treatment during pregnancy (OR = 2.4) and a low maternal platelet count during pregnancy or at delivery. These risk factors were not significantly associated with an increased risk of neonatal haemorrhagic complications. Conclusion In our population, we confirm the risk of severe nTP in case of maternal splenectomy or previous nTP. By monitoring the platelet count to its nadir, we identified three additional risk factors: maternal treatment during pregnancy and low maternal platelet count during pregnancy or low maternal platelet count at delivery.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T05:10:13Z
2024-01-10T15:50:43Z