Title :

Polycystic ovary syndrome phenotype does not have impact on oocyte morphology.

Author(s) :

Uk, Audrey [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]

Hôpital Jeanne de Flandre [Lille]
Decanter, Christine [Auteur]
Gamétogenèse et Qualité du Gamète - ULR 4308 [GQG]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Grysole, Camille [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Keller, Laura [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Behal, Helene [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Mauro, Silva [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Dewailly, Didier [Auteur]

Robin, Geoffroy [Auteur]

Gamétogenèse et Qualité du Gamète - ULR 4308 [GQG]
Hôpital Jeanne de Flandres
Barbotin, Anne-Laure [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]

Gamétogenèse et Qualité du Gamète - ULR 4308 [GQG]

Journal title :

Reprod Biol Endocrinol

Abbreviated title :

Reprod Biol Endocrinol

Volume number :

20

Pages :

7

Publication date :

2022-01-08

ISSN :

1477-7827

English keyword(s) :

Polycystic ovary syndrome
PCOS phenotypes
Oocyte morphology
Morphologic scores
ICSI

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Purpose The primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of oocytes was related to the polycystic ovary syndrome (PCOS) phenotype. ...
Show more >Purpose The primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of oocytes was related to the polycystic ovary syndrome (PCOS) phenotype. Methods We performed a retrospective cohort study in the IVF unit at the Lille University Medical Center (Lille, France) between 2006 and 2015. Oocyte morphology (fragmented first polar body, abnormal zona pellucida, large perivitelline space, material in perivitelline space, abnormal shape of oocyte, granular cytoplasm and intracytoplasmic vacuoles) was evaluated in PCOS women and according to different subgroup (depending on the presence or absence of the cardinal features polycystic ovarian morphology (PCOM), hyperandrogenism (HA), and oligo-anovulation (OA)). Results A total of 1496 metaphase II oocytes (n = 602 for phenotype A combining PCOM + HA + OA, n = 462 oocytes for phenotype C: PCOM + HA, and n = 432 for phenotype D: PCOM + OA) were assessed. The phenotypes A, C and D did not differ significantly with regard to the proportion of normal oocytes (adjusted percentages (95%CI): 35.2% (31.5 to 39.1%), 25.8% (21.9 to 29.9%) and 34.0% (29.7 to 38.6%), respectively: adjusted p = 0.13). Likewise, there were no significant intergroup differences in oocyte morphology. The ICSI outcome was not significantly associated with the PCOS phenotype. Conclusion The present study is the first to show that the PCOS phenotype (notably the presence vs. absence of OA and/or HA) is not significantly associated with the morphological quality of oocytes.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T05:11:47Z
2024-01-11T12:40:49Z