A comparison of changes in bone turnover ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
A comparison of changes in bone turnover markers after gastric bypass and sleeve gastrectomy, and their association with markers of interest.
Author(s) :
Paccou, Julien [Auteur]
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Thuillier, Dorothée [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Courtalin, Marion [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab (ex-pmoi)]
Pigny, Pascal [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Labreuche, Julien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Cortet, Bernard [Auteur]
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Thuillier, Dorothée [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Courtalin, Marion [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab (ex-pmoi)]
Pigny, Pascal [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Labreuche, Julien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Cortet, Bernard [Auteur]
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Journal title :
Surgery for Obesity and Related Diseases
Abbreviated title :
Surg Obes Relat Dis
Volume number :
18
Pages :
373-383
Publication date :
2022-01-08
ISSN :
1878-7533
English keyword(s) :
Bone turnover markers
Bariatric surgery
Roux-en-Y gastric bypass
Sleeve gastrectomy
Sclerostin
Bariatric surgery
Roux-en-Y gastric bypass
Sleeve gastrectomy
Sclerostin
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background
It is still debated whether differences in bone turnover markers (BTMs) exist between the 2 most popular bariatric surgery procedures (Roux-en-Y gastric bypass [RYGB] and sleeve gastrectomy [SG]).
Objectives
To ...
Show more >Background It is still debated whether differences in bone turnover markers (BTMs) exist between the 2 most popular bariatric surgery procedures (Roux-en-Y gastric bypass [RYGB] and sleeve gastrectomy [SG]). Objectives To compare changes in BTMs after RYGB and SG, and to investigate their association with predefined markers of interest. Setting University hospital, Lille, France. Methods An ancillary investigation of a prospective cohort was conducted. SG patients with severe obesity ≥40 years were matched one-to-one to RYGB patients for age, sex, body mass index (BMI), and menopausal status. BTMs, as well as predefined markers of interest, were measured at baseline, 12, and 24 months after bariatric surgery. Results Sixty-four patients (66% women) had a mean (standard deviation [SD]) age of 49.6 years (5.1) and a mean (SD) BMI of 45.0 kg/m2 (6.0). From baseline to 12 months, a significant increase in BTMs was observed in both groups (P < .001). Moreover, RYGB was associated with a greater increase in C-terminal telopeptide (β-CTX) and procollagen type 1 N-terminal propeptide (PINP) compared with SG (P < .0001). From 12 to 24 months, a significant decrease in BTMs was observed in both groups, but no significant differences were found between RYGB and SG. However, BTMs did not return to baseline levels. The changes in PINP and β-CTX at 12 months were independently associated with the type of surgical procedure, after adjusting for weight or each predefined marker of interest (all P < .0001). Conclusion RYGB was associated with a greater increase in BTMs than SG at 12 and 24 months.Show less >
Show more >Background It is still debated whether differences in bone turnover markers (BTMs) exist between the 2 most popular bariatric surgery procedures (Roux-en-Y gastric bypass [RYGB] and sleeve gastrectomy [SG]). Objectives To compare changes in BTMs after RYGB and SG, and to investigate their association with predefined markers of interest. Setting University hospital, Lille, France. Methods An ancillary investigation of a prospective cohort was conducted. SG patients with severe obesity ≥40 years were matched one-to-one to RYGB patients for age, sex, body mass index (BMI), and menopausal status. BTMs, as well as predefined markers of interest, were measured at baseline, 12, and 24 months after bariatric surgery. Results Sixty-four patients (66% women) had a mean (standard deviation [SD]) age of 49.6 years (5.1) and a mean (SD) BMI of 45.0 kg/m2 (6.0). From baseline to 12 months, a significant increase in BTMs was observed in both groups (P < .001). Moreover, RYGB was associated with a greater increase in C-terminal telopeptide (β-CTX) and procollagen type 1 N-terminal propeptide (PINP) compared with SG (P < .0001). From 12 to 24 months, a significant decrease in BTMs was observed in both groups, but no significant differences were found between RYGB and SG. However, BTMs did not return to baseline levels. The changes in PINP and β-CTX at 12 months were independently associated with the type of surgical procedure, after adjusting for weight or each predefined marker of interest (all P < .0001). Conclusion RYGB was associated with a greater increase in BTMs than SG at 12 and 24 months.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Submission date :
2023-11-15T05:12:46Z
2024-04-15T13:42:39Z
2024-04-15T13:42:39Z