High Prevalence of 5T4/Trophoblast ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
High Prevalence of 5T4/Trophoblast Glycoprotein in Soft Tissue Sarcomas
Auteur(s) :
Groothuis, P. [Auteur]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Italiano, A. [Auteur]
Institut Bergonié [Bordeaux]
Kotecki, N. [Auteur]
Dijcks, F. [Auteur]
Dokter, W. [Auteur]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Italiano, A. [Auteur]
Institut Bergonié [Bordeaux]
Kotecki, N. [Auteur]
Dijcks, F. [Auteur]
Dokter, W. [Auteur]
Titre de la revue :
Cancers
Nom court de la revue :
Cancers (Basel)
Numéro :
13
Pagination :
4841
Date de publication :
2021
ISSN :
2072-6694
Mot(s)-clé(s) en anglais :
soft tissue sarcoma
5T4
trophoblast glycoprotein
immunohistochemistry
cell surface antigen
5T4
trophoblast glycoprotein
immunohistochemistry
cell surface antigen
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The expression of 5T4/trophoblast glycoprotein was evaluated in several histological subtypes of soft tissue sarcoma (STS) to determine whether the prevalence and level of expression of this membrane-associated glycoprotein ...
Lire la suite >The expression of 5T4/trophoblast glycoprotein was evaluated in several histological subtypes of soft tissue sarcoma (STS) to determine whether the prevalence and level of expression of this membrane-associated glycoprotein is sufficient for use in targeted therapies. Tumor tissue microarrays containing cores from different histological subtypes of STS were stained using a standardized immunohistochemical staining method to detect 5T4; the level of staining was assessed using a semi-quantitative scoring method. No 5T4 staining was seen in the angiosarcomas and liposarcomas investigated in this study. 5T4 staining in the other STS subtypes was seen in more than 50% of cases, warranting further investigation into whether this antigen could evoke an anti-tumor immune response or can be used as target for the delivery of more potent toxins through antibody drug conjugates.Lire moins >
Lire la suite >The expression of 5T4/trophoblast glycoprotein was evaluated in several histological subtypes of soft tissue sarcoma (STS) to determine whether the prevalence and level of expression of this membrane-associated glycoprotein is sufficient for use in targeted therapies. Tumor tissue microarrays containing cores from different histological subtypes of STS were stained using a standardized immunohistochemical staining method to detect 5T4; the level of staining was assessed using a semi-quantitative scoring method. No 5T4 staining was seen in the angiosarcomas and liposarcomas investigated in this study. 5T4 staining in the other STS subtypes was seen in more than 50% of cases, warranting further investigation into whether this antigen could evoke an anti-tumor immune response or can be used as target for the delivery of more potent toxins through antibody drug conjugates.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
CHU Lille
Date de dépôt :
2023-11-15T05:46:34Z
2024-02-22T09:42:21Z
2024-02-22T09:42:21Z
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