Title :

Impact of early life nutrition on gut health in children: a prospective clinical study

Author(s) :

Ley, Delphine [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Beghin, Laurent [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Morcel, J. [Auteur]
Flamein, F. [Auteur]
Garabedian, Charles [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Accart, B. [Auteur]
Drumez, Elodie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Labreuche, Julien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Gottrand, fréderic [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Hermann, Emmanuel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Journal title :

BMJ Open

Abbreviated title :

BMJ Open

Volume number :

11

Pages :

e050432

Publication date :

2021

ISSN :

2044-6055

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Download PDFPDF XML Gastroenterology and hepatology Protocol Impact of early life nutrition on gut health in children: a prospective clinical study Delphine Ley1, Laurent Beghin1,2, Jules Morcel1,2, Florence ...
Show more >Download PDFPDF XML Gastroenterology and hepatology Protocol Impact of early life nutrition on gut health in children: a prospective clinical study Delphine Ley1, Laurent Beghin1,2, Jules Morcel1,2, Florence Flamein2, Charles Garabedian3,4, Bertrand Accart5, Elodie Drumez4,6, Julien Labreuche4,6, Frederic Gottrand1,2, http://orcid.org/0000-0003-0971-4918Emmanuel Hermann1 Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France Univ. Lille, Inserm, CHU Lille, CIC-1403 Inserm-CHU, F-59000 Lille, France Univ. Lille, CHU Lille, Department of Obstetrics & Gynecology, F-59000 Lille, France Univ. Lille, CHU Lille, ULR 2694-METRICS: évaluation des technologies de santé et des pratiques médicales, F-59000 Lille, France CHU Lille - Inserm - UL, CRB/CIC1403, F-59037 Lille, France CHU Lille, Department of Biostatistics, F-59000 Lille, France Correspondence to Dr Emmanuel Hermann; emmanuel.hermann@univ-lille.fr Abstract Introduction The first 1000 days of life could contribute to individual susceptibility to the later development of chronic non-communicable diseases. Nutrition in early life appears to be an important determinant factor for a sustainable child’s health. In this study, we propose to investigate the impact of exclusive breast feeding on gut health in children. Methods and analysis A prospective cohort of newborns (n=350) will be recruited at birth and followed up to 4 years of age. The main objective is to evaluate the link between exclusive breast feeding for at least 3 months and the gut health of the child at 4 years. The primary endpoint of assessment of gut health will be based on the non-invasive measurement of faecal secretory IgA (sIgA) as a sensitive biomarker of the intestinal ecosystem. The presence of gastrointestinal disorders will be defined according to the clinical criteria of Rome IV. Information on parent’s nutritional habits and life style, breastfeeding duration and child’s complementary feeding will be collected along the follow-up. Cord blood cells and plasma at birth will be purified for further analysis. The meconium and stools collected at birth, 6 months, 2 years and 4 years of age will allow sIgA analysis. Ethics and dissemination This clinical study has obtained the approval from the national ethical committee. We plan to publish the results of the study in peer-review journals and by means of national and international conference.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T05:54:54Z
2024-02-08T09:10:06Z
2024-02-08T10:04:35Z
2024-02-27T15:14:08Z