Title :

Hysterectomy, non-malignant gynecological diseases, and the risk of incident hypertension: The E3N prospective cohort.

Author(s) :

Madika, Anne-Laure [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Macdonald, C. J. [Auteur]
Gelot, A. [Auteur]
Hitier, S. [Auteur]
Mounier-Vehier, Claire [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Béraud, G. [Auteur]
Kvaskoff, M. [Auteur]
Boutron-Ruault, M. C. [Auteur]
Bonnet, F. [Auteur]

Journal title :

Maturitas

Abbreviated title :

Maturitas

Volume number :

150

Pages :

p. 22-29

Publication date :

2021-08

ISSN :

1873-4111

English keyword(s) :

Endometriosis
Uterine fibroids
Hypertension
Hysterectomy
Epidemiology

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objectives While it has been reported that women with uterine fibroids or endometriosis are commonly overweight and hypertensive, the association between non-malignant gynecological diseases and the risk of hypertension ...
Show more >Objectives While it has been reported that women with uterine fibroids or endometriosis are commonly overweight and hypertensive, the association between non-malignant gynecological diseases and the risk of hypertension has been little studied prospectively. The aim of this study was to investigate in a large French cohort of women whether a history of hysterectomy, uterine fibroids, or endometriosis was prospectively related to an increased risk of incident hypertension. Study design We analyzed 50,286 women from the E3N cohort who were free of hypertension at baseline, with a median follow-up of 16.4 years. Main outcome measures Gynecological diseases were based on self-report. Cox proportional hazards models with age as the timescale were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Covariates included smoking status, body mass index (BMI), physical activity, and hormonal factors. Results A total of 12,073 women (24%) developed hypertension during follow-up. Women with a history of hysterectomy had an increased risk of incident hypertension, which persisted after adjustment for potential confounding factors (adjusted HR=1.18, 95% CI 1.12–1.24). Risk was similar in women with hysterectomy with or without oophorectomy. Risk of hypertension was higher in women with a history of endometriosis (HRendometriosis 1.19, 95%CI 1.11–1.22) or uterine fibroids (HRfibroids 1.18, 95%CI 1.13–1.22), irrespective of hysterectomy. Associations were similar after further adjustment for BMI. Conclusions Hysterectomy and non-malignant gynecological diseases were associated with an increased risk of hypertension in this large prospective study. Women with these conditions may benefit from blood pressure monitoring.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T06:12:03Z
2024-02-26T13:40:50Z