Titre :

Low prevalence of tissue detection of cefepime and daptomycin used as empirical treatment during revision for periprosthetic joint infections: results of a prospective multicenter study

Auteur(s) :

Robineau, Olivier [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Talagrand-Reboulh, E. [Auteur]
Brunschweiler, B. [Auteur]
Jehl, F. [Auteur]
Beltrand, E. [Auteur]
Rousseau, F. [Auteur]
Blondiaux, N. [Auteur]
Grillon, A. [Auteur]
Joseph, C. [Auteur]
Lambotte, P. [Auteur]
Boyer, P. [Auteur]
Senneville, Eric [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Titre de la revue :

European Journal of Clinical Microbiology and Infectious Diseases

Nom court de la revue :

Eur J Clin Microbiol Infect Dis

Numéro :

40

Pagination :

p. 2285–2294

Date de publication :

2021

ISSN :

1435-4373

Mot(s)-clé(s) en anglais :

Cefepime
Daptomycin
Periprosthetic joint infection
Tourniquet
Inhibitory quotient
Empirical antibiotic therapy
Dosage

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Data demonstrating that antibiotics administered intraoperatively in patients with surgical revision for periprosthetic joint infection achieve concentrations exceeding minimal inhibitory concentrations of the identified ...
Lire la suite >Data demonstrating that antibiotics administered intraoperatively in patients with surgical revision for periprosthetic joint infection achieve concentrations exceeding minimal inhibitory concentrations of the identified bacteria at the surgical site when the new implant is inserted are lacking. We prospectively included patients with periprosthetic joint infection operated with one- or two-stage replacement during which cefepime (2g)-daptomycin (10mg/kg) combination was administered intravenously as intraoperative empirical antibiotic treatment. Three biopsies (two bones and one synovial membrane) were taken from each patient just before the insertion of the new implant. Eighteen adults of median age 68 years were included. Knee was involved in 10 patients (55.6%) and surgery consisted in one-/two-stage replacement in 11/7 patients. A tourniquet was used during the intervention in the 10 patients with knee prosthesis. Among 54 tissue samples, cefepime and daptomycin were detected respectively in 35 (64.8%) and 21 (38.9%) cases (P=0.01). A total of 17 bacteria dominated by staphylococci (n=14) were identified in 10 patients; tissue inhibitory quotient calculated in 51 samples was >1 in 22 cases (43.1%) for cefepime and in 16 cases (31.4%) for daptomycin. The proportion of tissue samples with detectable antibiotic was significantly higher in hip versus knee prosthesis (P=0.03). The present study suggests that intraoperative empirical administration of cefepime-daptomycin combination during septic prosthetic joint replacement results in a high proportion of tissue samples in which at least one of the two antibiotics was not detected or at a low concentration despite satisfactory concomitant blood serum concentrations.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T06:37:11Z
2024-02-15T10:59:48Z