Title :

A pharmacoepidemiological study of the association of suicide reattempt risk with psychotropic drug exposure

Author(s) :

Demesmaeker, Alice [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Chazard, Emmanuel [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Vaiva, Guillaume [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Amad, Ali [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]

Journal title :

Journal of Psychiatric Research

Abbreviated title :

J Psychiatr Res

Volume number :

138

Pages :

p. 256-263

Publication date :

2021-06

ISSN :

1879-1379

English keyword(s) :

Suicide
Suicide attempt
Pharmacoepidemiology
Psychotropic drug

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Introduction Recent pharmacoepidemiological studies have suggested that consumption of certain classes of psychotropic drugs could be considered protective or risk factors for suicidal behaviour. The aim of the study ...
Show more >Introduction Recent pharmacoepidemiological studies have suggested that consumption of certain classes of psychotropic drugs could be considered protective or risk factors for suicidal behaviour. The aim of the study was to evaluate the association between the risk of suicide reattempt within 6 and 14 months after a suicide attempt (SA) with the use of different classes of psychotropic drugs, combination pairs and treatment adequacy from inclusion through 6 and 14 months post-SA. Method A prospective observational cohort of 972 subjects from the ALGOS study from January 2010 to February 2013 was used to evaluate the association of risk of suicide reattempt within 6 and 14 months with the use of different classes of psychotropic drugs (antidepressants, anxiolytics, antipsychotics, lithium, anticonvulsants, analgesics, opioid maintenance therapy and maintenance treatment for alcohol dependence). A multivariable Cox model was performed after imputation of missing data using the multiple imputation method. Results Our main results did not show an association between psychotropic drug use and suicide reattempt after 6 months of follow-up. We demonstrated that the use of benzodiazepines (HR = 1.87 [1.25; 2.81], p < 0.01) and hypnotics (HR = 1.49 [1.03; 2.17], p = 0.04) or a combination of both (HR = 1.80 [1.17; 2.72], p = 0.01) were associated with suicide reattempt within 14 months after a previous SA. Conclusion The early identification of a positive association between psychotropic drugs and the risk of suicidal behaviour is extremely important for prevention of suicide reattempts. Special precautions should be considered when prescribing psychotropic drugs for these subjects, particularly those at risk of suicide reattempt.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T06:51:16Z
2024-02-26T13:30:59Z
2024-02-26T13:32:54Z