Title :

Breast milk apelin level increases with maternal obesity and high-fat feeding during lactation.

Author(s) :

Marousez, Lucie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Hanssens, S. [Auteur]
Madjid, Laura [Auteur]
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011
Petit, Celine [Auteur]
Pourpe, Charlène [Auteur]
Besengez, Capucine [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Rakza, Thameur [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Storme, Laurent [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Deruelle, Philippe [Auteur]
Lesage, Jean [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Eberle, Delphine [Auteur]
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Journal title :

International Journal of Obesity

Abbreviated title :

Int J Obes (Lond)

Volume number :

45

Pages :

p. 1052–1060

Publication date :

2021

ISSN :

1476-5497

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective Recent evidence indicates that levels of breast milk (BM) hormones such as leptin can fluctuate with maternal adiposity, suggesting that BM hormones may signal maternal metabolic and nutritional environments ...
Show more >Objective Recent evidence indicates that levels of breast milk (BM) hormones such as leptin can fluctuate with maternal adiposity, suggesting that BM hormones may signal maternal metabolic and nutritional environments to offspring during postnatal development. The hormone apelin is highly abundant in BM but its regulation during lactation is completely unknown. Here, we evaluated whether maternal obesity and overnutrition impacted BM apelin and leptin levels in clinical cohorts and lactating rats. Methods BM and plasma samples were collected from normal-weight and obese breastfeeding women, and from lactating rats fed a control or a high fat (HF) diet during lactation. Apelin and leptin levels were assayed by ELISA. Mammary gland (MG) apelin expression and its cellular localization in lactating rats was measured by quantitative RT-PCR and immunofluorescence, respectively. Results BM apelin levels increased with maternal BMI, whereas plasma apelin levels decreased. BM apelin was also positively correlated with maternal insulin and C-peptide levels. In rats, maternal HF feeding exclusively during lactation was sufficient to increase BM apelin levels and decrease its plasma concentration without changing body weight. In contrast, BM leptin levels increased with maternal BMI in humans, but did not change with maternal HF feeding during lactation in rats. Apelin is highly expressed in the rat MG during lactation and was mainly localized to mammary myoepithelial cells. We found that MG apelin gene expression was up-regulated by maternal HF diet and positively correlated with BM apelin content and maternal insulinemia. Conclusions Our study indicates that BM apelin levels increase with long- and short-term overnutrition, possibly via maternal hyperinsulinemia and transcriptional upregulation of MG apelin expression in myoepithelial cells. Apelin regulates many physiological processes, including energy metabolism, digestive function, and development. Further studies are needed to unravel the consequences of such changes in offspring development.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Submission date :

2023-11-15T07:12:57Z
2023-12-22T13:53:12Z
2024-02-27T14:38:47Z