Expression and prognostic significance of ...
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Article dans une revue scientifique: Article original
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Title :
Expression and prognostic significance of PDGF ligands and receptors across soft tissue sarcomas.
Author(s) :
Brahmi, M. [Auteur]
Centre Léon Bérard [Lyon]
Lesluyes, T. [Auteur]
Université de Bordeaux [UB]
Dufresne, A. [Auteur]
Toulmonde, M. [Auteur]
Institut Bergonié [Bordeaux]
Italiano, A. [Auteur]
Institut Bergonié [Bordeaux]
Mir, O. [Auteur]
Département de médecine oncologique [Gustave Roussy]
Le Cesne, A. [Auteur]
Département de médecine oncologique [Gustave Roussy]
Valentin, T. [Auteur]
Institut Claudius Regaud
Chevreau, C. [Auteur]
Institut Claudius Regaud
Bonvalot, S. [Auteur]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Coindre, J. M. [Auteur]
Université de Bordeaux [UB]
Le Guellec, S. [Auteur]
Institut Claudius Regaud
Le Loarer, F. [Auteur]
Institut Bergonié [Bordeaux]
Karanian, M. [Auteur]
Centre Léon Bérard [Lyon]
Blay, J. Y. [Auteur]
Centre Léon Bérard [Lyon]
Université Claude Bernard Lyon 1 [UCBL]
Chibon, F. [Auteur]
Institut Claudius Regaud
Centre Léon Bérard [Lyon]
Lesluyes, T. [Auteur]
Université de Bordeaux [UB]
Dufresne, A. [Auteur]
Toulmonde, M. [Auteur]
Institut Bergonié [Bordeaux]
Italiano, A. [Auteur]
Institut Bergonié [Bordeaux]
Mir, O. [Auteur]
Département de médecine oncologique [Gustave Roussy]
Le Cesne, A. [Auteur]
Département de médecine oncologique [Gustave Roussy]
Valentin, T. [Auteur]
Institut Claudius Regaud
Chevreau, C. [Auteur]
Institut Claudius Regaud
Bonvalot, S. [Auteur]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Coindre, J. M. [Auteur]
Université de Bordeaux [UB]
Le Guellec, S. [Auteur]
Institut Claudius Regaud
Le Loarer, F. [Auteur]
Institut Bergonié [Bordeaux]
Karanian, M. [Auteur]
Centre Léon Bérard [Lyon]
Blay, J. Y. [Auteur]
Centre Léon Bérard [Lyon]
Université Claude Bernard Lyon 1 [UCBL]
Chibon, F. [Auteur]
Institut Claudius Regaud
Journal title :
ESMO Open
Abbreviated title :
ESMO Open
Volume number :
6
Pages :
100037
Publication date :
2021-02
ISSN :
2059-7029
English keyword(s) :
sarcoma
PDGF
PDGFR
expression level
prognostic factor
PDGF
PDGFR
expression level
prognostic factor
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background
While the anti-PDGFRA antibody olaratumab failed to confirm an impact on survival in unselected advanced soft tissue sarcoma (STS) patients, the level of expression and the prognosis of platelet-derived growth ...
Show more >Background While the anti-PDGFRA antibody olaratumab failed to confirm an impact on survival in unselected advanced soft tissue sarcoma (STS) patients, the level of expression and the prognosis of platelet-derived growth factor (PDGF) receptors and ligands in STS remain unclear. Patients and methods We analyzed PDGF ligands and receptors' expression levels in a series of 255 patients with different histologies of STS [gastrointestinal stromal tumor (GIST), myxoid liposarcoma (MLPS), sarcoma with complex genomics, synovial sarcoma (SyS)] with Agilent single-color micro-arrays. We explored expression levels as prognostic values in univariate and multivariate analysis using R software (version 3.4.2). Results Complex patterns of correlation of expression between ligands and receptors were observed for each histotype. PDGFA levels were highest in SyS and lowest in MLPS (P < 4 × 10−9), PDGFB and C levels were lower in GIST (P < 2 × 10−15 and P < 3 × 10−9) while PDGFD expression was similar across histological subtypes. PDGF receptor (PDGFR) A expression was lowest in MLPS (P < 0.002), whereas PDGFRB and L expressions were lowest in GIST and SyS (P < 0.0004). Interestingly, high PDGFA expression levels were associated with higher risk of metastasis (P = 0.006), whereas PDGFD levels above average were associated with a reduced risk of metastasis (P = 0.01) in univariate and multivariate analysis. Conclusions The expression of PDGF ligands and receptors varies across sarcoma histological subtypes. PDGFA and D expression levels independently and inversely correlate with the risk of metastatic relapse.Show less >
Show more >Background While the anti-PDGFRA antibody olaratumab failed to confirm an impact on survival in unselected advanced soft tissue sarcoma (STS) patients, the level of expression and the prognosis of platelet-derived growth factor (PDGF) receptors and ligands in STS remain unclear. Patients and methods We analyzed PDGF ligands and receptors' expression levels in a series of 255 patients with different histologies of STS [gastrointestinal stromal tumor (GIST), myxoid liposarcoma (MLPS), sarcoma with complex genomics, synovial sarcoma (SyS)] with Agilent single-color micro-arrays. We explored expression levels as prognostic values in univariate and multivariate analysis using R software (version 3.4.2). Results Complex patterns of correlation of expression between ligands and receptors were observed for each histotype. PDGFA levels were highest in SyS and lowest in MLPS (P < 4 × 10−9), PDGFB and C levels were lower in GIST (P < 2 × 10−15 and P < 3 × 10−9) while PDGFD expression was similar across histological subtypes. PDGF receptor (PDGFR) A expression was lowest in MLPS (P < 0.002), whereas PDGFRB and L expressions were lowest in GIST and SyS (P < 0.0004). Interestingly, high PDGFA expression levels were associated with higher risk of metastasis (P = 0.006), whereas PDGFD levels above average were associated with a reduced risk of metastasis (P = 0.01) in univariate and multivariate analysis. Conclusions The expression of PDGF ligands and receptors varies across sarcoma histological subtypes. PDGFA and D expression levels independently and inversely correlate with the risk of metastatic relapse.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Submission date :
2023-11-15T07:16:13Z
2024-04-19T09:53:43Z
2024-04-19T09:53:43Z
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