Title :

Human milk oligosaccharides, infant growth, and adiposity over the first 4 months of lactation

Author(s) :

Binia, A. [Auteur]
Lavalle, L. [Auteur]
Chen, C. [Auteur]
Austin, S. [Auteur]
Agosti, M. [Auteur]
Al-Jashi, I. [Auteur]
Pereira, A. B. [Auteur]
Costeira, M. J. [Auteur]
Silva, M. G. [Auteur]
Marchini, G. [Auteur]
Martínez-Costa, C. [Auteur]
Stiris, T. [Auteur]
Stoicescu, S. M. [Auteur]
Vanpée, M. [Auteur]
Rakza, Thameur [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Billeaud, C. [Auteur]
Picaud, J. C. [Auteur]
Domellöf, M. [Auteur]
Adams, R. [Auteur]
Castaneda-Gutierrez, E. [Auteur]
Sprenger, N. [Auteur]

Journal title :

Pediatric Research

Abbreviated title :

Pediatr Res

Volume number :

90

Pages :

p. 684–693

Publication date :

2021

ISSN :

1530-0447

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: The relationship between human milk oligosaccharides (HMOs) and infant growth and adiposity is not fully understood and comprehensive studies are missing from the current literature. METHODS: We screened and ...
Show more >BACKGROUND: The relationship between human milk oligosaccharides (HMOs) and infant growth and adiposity is not fully understood and comprehensive studies are missing from the current literature. METHODS: We screened and recruited 370 healthy, pregnant women and their infants from seven European countries. Breastmilk samples were collected using standardized procedures at six time points over 4 months, as were infant parameters. Correlations and associations between HMO area under the curve, anthropometric data, and fat mass at 4 months were tested. RESULTS: Lacto-N-neotetraose had a negative correlation with the change in length (rs = −0.18, P = 0.02). Sialyllacto-N-tetraose c (LSTc) had a positive correlation with weight for length (rs = 0.19, P = 0.015). Infants at the 25th upper percentile were fed milk higher in 3′-sialyllactose and LSTc (P = 0.017 and P = 0.006, respectively) compared to the lower 25th percentile of the weight-forlength z-score gain over 4 months of lactation. No significant associations between growth and body composition and Lewis or secretor-dependent HMOs like 2′-fucosyllactose were identified. CONCLUSIONS: Changes in the HMO composition of breastmilk during the first 4 months appear to have little influence on infant growth and body composition in this cohort of healthy mothers and infants.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T07:21:26Z
2024-02-08T14:03:38Z