Title :

Pre-procedural predictive factors of symptomatic intracranial hemorrhage after thrombectomy in stroke.

Author(s) :

Venditti, L. [Auteur]

Chassin, O. [Auteur]
Ancelet, C. [Auteur]
Université Paris-Saclay
Legris, N. [Auteur]
Sarov, M. [Auteur]
Lapergue, B. [Auteur]
Mihalea, C. [Auteur]
Ozanne, A. [Auteur]
Gallas, S. [Auteur]
Cortese, J. [Auteur]
Chalumeau, V. [Auteur]
Ikka, L. [Auteur]
Caroff, J. [Auteur]
Labreuche, Julien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Spelle, L. [Auteur]
Denier, C. [Auteur]

Journal title :

Journal of Neurology

Abbreviated title :

J Neurol

Volume number :

268

Pages :

p. 1867–1875

Publication date :

2021

ISSN :

1432-1459

English keyword(s) :

Ischemic stroke
Symptomatic intracranial hemorrhage
Predictive factors
Thrombectomy

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective Symptomatic intracerebral hemorrhage (sICH) is a common complication of acute ischemic stroke (AIS) associated with limited treatments and poor outcomes. We aimed to identify predictive factors of sICH in ...
Show more >Objective Symptomatic intracerebral hemorrhage (sICH) is a common complication of acute ischemic stroke (AIS) associated with limited treatments and poor outcomes. We aimed to identify predictive factors of sICH in patients with AIS following mechanical thrombectomy (MT) in a real-world setting. Methods Patients with large vessel occlusion of the anterior circulation treated with MT were consecutively included in a prospective monocentric cohort. Clinical, biological, and radiological parameters were collected to identify pre-procedural predictors for sICH. Results 637 patients were included in our study. Magnetic resonance imaging was performed on most patients (86.7%). sICH occurred in 55 patients (8.6%). 428 patients (67.2%) were treated with intravenous thrombolysis. After multivariate analysis, prior use of antiplatelet therapies (odd ratio (OR) 1.84, 95% confidence interval (CI) 1.01–3.32), high C-reactive protein (OR per standard deviation (SD) increase 1.28, 95% 1.01–1.63), elevated mean arterial blood pressure (OR per 10 mmHg increase 1.22, 95% CI 1.03–1.44), hyperglycemia (OR per one SD-log increase 1.38, 95% CI 1.02–1.87), and low ASPECTS (OR per 1-point decrease 1.42, 95% CI 1.12–1.80) were found to be independent predictive factors of sICH. The pre-procedural predictors did not change when the absence of successful recanalization was considered as a covariate. Patients with strokes of unknown onset time were not especially vulnerable for sICH. Conclusion sICH after MT was associated with several pre-procedural risk factors: prior use of antiplatelet therapies, high C-reactive protein and hyperglycemia at baseline, elevated mean arterial blood pressure, and low ASPECTS.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T07:26:09Z
2024-02-21T08:19:23Z