Clot Burden Score and Collateral Status ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
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Title :
Clot Burden Score and Collateral Status and Their Impact on Functional Outcome in Acute Ischemic Stroke.
Author(s) :
Derraz, I. [Auteur]
Hôpital Gui de Chauliac [CHU Montpellier]
Pou, M. [Auteur]
Labreuche, Julien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Legrand, L. [Auteur]
Centre Hospitalier Sainte Anne [Paris]
Soize, S. [Auteur]
Tisserand, M. [Auteur]
Rosso, C. [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Piotin, M. [Auteur]
Boulouis, G. [Auteur]
Oppenheim, C. [Auteur]
Naggara, O. [Auteur]
Bracard, S. [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Clarençon, F. [Auteur]
Lapergue, B. [Auteur]
Bourcier, R. [Auteur]
Hôpital Gui de Chauliac [CHU Montpellier]
Pou, M. [Auteur]
Labreuche, Julien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Legrand, L. [Auteur]
Centre Hospitalier Sainte Anne [Paris]
Soize, S. [Auteur]
Tisserand, M. [Auteur]
Rosso, C. [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Piotin, M. [Auteur]
Boulouis, G. [Auteur]
Oppenheim, C. [Auteur]
Naggara, O. [Auteur]
Bracard, S. [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Clarençon, F. [Auteur]
Lapergue, B. [Auteur]
Bourcier, R. [Auteur]
Journal title :
American Journal of Neuroradiology
Abbreviated title :
AJNR Am J Neuroradiol
Volume number :
42
Pages :
p. 42-48
Publication date :
2021-01-01
ISSN :
1936-959X
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND AND PURPOSE: Collateral status and thrombus length have been independently associated with functional outcome in patients with acute ischemic stroke. It has been suggested that thrombus length would influence ...
Show more >BACKGROUND AND PURPOSE: Collateral status and thrombus length have been independently associated with functional outcome in patients with acute ischemic stroke. It has been suggested that thrombus length would influence functional outcome via interaction with the collateral circulation. We investigated the individual and combined effects of thrombus length assessed by the clot burden score and collateral status assessed by a FLAIR vascular hyperintensity–ASPECTS rating system on functional outcome (mRS). MATERIALS AND METHODS: Patients with anterior circulation acute ischemic stroke due to large-vessel occlusion from the ASTER and THRACE trials treated with endovascular thrombectomy were pooled. The clot burden score and FLAIR vascular hyperintensity score were determined on MR imaging obtained before endovascular thrombectomy. Favorable outcome was defined as an mRS score of 0–2 at 90 days. Association of the clot burden score and the FLAIR vascular hyperintensity score with favorable outcome (individual effect and interaction) was examined using logistic regression models. RESULTS: Of the 326 patients treated by endovascular thrombectomy with both the clot burden score and FLAIR vascular hyperintensity assessment, favorable outcome was observed in 165 (51%). The rate of favorable outcome increased with clot burden score (smaller clots) and FLAIR vascular hyperintensity (better collaterals) values. The association between clot burden score and functional outcome was significantly modified by the FLAIR vascular hyperintensity score, and this association was stronger in patients with good collaterals, with an adjusted OR = 6.15 (95% CI, 1.03–36.81). CONCLUSIONS: The association between the clot burden score and functional outcome varied for different collateral scores. The FLAIR vascular hyperintensity score might be a valuable prognostic factor, especially when contrast-based vascular imaging is not available.Show less >
Show more >BACKGROUND AND PURPOSE: Collateral status and thrombus length have been independently associated with functional outcome in patients with acute ischemic stroke. It has been suggested that thrombus length would influence functional outcome via interaction with the collateral circulation. We investigated the individual and combined effects of thrombus length assessed by the clot burden score and collateral status assessed by a FLAIR vascular hyperintensity–ASPECTS rating system on functional outcome (mRS). MATERIALS AND METHODS: Patients with anterior circulation acute ischemic stroke due to large-vessel occlusion from the ASTER and THRACE trials treated with endovascular thrombectomy were pooled. The clot burden score and FLAIR vascular hyperintensity score were determined on MR imaging obtained before endovascular thrombectomy. Favorable outcome was defined as an mRS score of 0–2 at 90 days. Association of the clot burden score and the FLAIR vascular hyperintensity score with favorable outcome (individual effect and interaction) was examined using logistic regression models. RESULTS: Of the 326 patients treated by endovascular thrombectomy with both the clot burden score and FLAIR vascular hyperintensity assessment, favorable outcome was observed in 165 (51%). The rate of favorable outcome increased with clot burden score (smaller clots) and FLAIR vascular hyperintensity (better collaterals) values. The association between clot burden score and functional outcome was significantly modified by the FLAIR vascular hyperintensity score, and this association was stronger in patients with good collaterals, with an adjusted OR = 6.15 (95% CI, 1.03–36.81). CONCLUSIONS: The association between the clot burden score and functional outcome varied for different collateral scores. The FLAIR vascular hyperintensity score might be a valuable prognostic factor, especially when contrast-based vascular imaging is not available.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Submission date :
2023-11-15T07:48:06Z
2023-12-04T15:06:43Z
2023-12-04T15:54:20Z
2023-12-07T13:34:14Z
2023-12-04T15:06:43Z
2023-12-04T15:54:20Z
2023-12-07T13:34:14Z
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