Titre :

Spatial analysis of hypospadias cases in northern France: taking clinical data into account.

Auteur(s) :

Lauriot Dit Prevost, Arthur [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Genin, Michaël [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Occelli, Florent [Auteur]
Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515
Priso, René-Hilaire [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Besson, Rémi [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Lanier, Caroline [Auteur]
Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515
Sharma, Dyuti [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Titre de la revue :

BMC Pediatrics

Nom court de la revue :

BMC Pediatr

Numéro :

20

Pagination :

442

Date de publication :

2020-09-26

ISSN :

1471-2431

Mot(s)-clé(s) en anglais :

Birth defect
Congenital malformation
Spatial cluster detection
Geographical analysis
Ecological regression
Endocrine-disrupting chemicals
Deprivation index

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Strong evidence for a causal role of environmental factors in a congenital anomaly is still difficult to produce. The collection of statistical data is crucial for gaining a better understanding of the ...
Lire la suite >Background Strong evidence for a causal role of environmental factors in a congenital anomaly is still difficult to produce. The collection of statistical data is crucial for gaining a better understanding of the epidemiology and pathophysiology of these anomalies. We aimed to evaluate spatial variations in hypospadias within our region and it’s association to socioeconomic and ecological factors, taking clinical data into account. Methods All boys with hypospadias born in northern France and seen in Lille University Medical Center (Lille, France) between 1999 and 2012 were included in the analysis. We retrospectively collected geographic data, clinical data (especially known confounding factors associated with an elevated risk of hypospadias), and demographic, socio-economic and ecological data. We analyzed the entire study population and subsequently the subset of boys lacking confounding factors. Results The study sample of 975 cases of hypospadias over the 13-year period resulted in an incidence of 25.4/10,000 male births, and was characterized by significant spatial heterogeneity (p < 0.005) and autocorrelation (p < 0.001). We detected two high-incidence clusters that differed with regard to their land use. After the exclusion of 221 patients with confounding factors, two high-incidence clusters with significant disease risks (1.65 and 1.75, respectively; p < 0.001) and a significant difference in land use (p < 0.001) again appeared. The first cluster contained a higher median [interquartile range] proportion of artificialized land (0.40 [0.22;0.47]) than the remaining “neutral areas” (0.19 [0.08;0.53]) did (p < 0.001). Conversely, the second cluster contained a higher median proportion of rural land (0.90 [0.78;0.96]) than the “neutral areas” (0.81 [0.47;0.92]) did (p < 0.001). The median deprivation index was significantly lower in the urban cluster (0.47 [0.42;0.55]) and significantly higher in the rural cluster (0.69 [0.56;0.73]) (p < 0.001). Conclusions Our results evidenced the heterogeneous spatial distribution of cases of hypospadias in northern France. We identified two clusters with different environmental and social patterns – even after the exclusion of known confounding factors.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T08:07:14Z
2023-12-18T16:38:37Z