Titre :

A Time-Dependent Propensity Score Matching Approach to Assess Epinephrine Use on Patients Survival Within Out-of-Hospital Cardiac Arrest Care.

Auteur(s) :

Canon, Valentine [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Hubert, Hervé [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Chouihed, Tahar [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Claustre, Clément [Auteur]
WIEL, Eric [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Escutnaire, Josephine [Auteur]
Santé publique : épidémiologie et qualité des soins - EA 2694
Jaeger, Déborah [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Vilhelm, Christian [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Segal, Nicolas [Auteur]
The University of New Mexico [Albuquerque]
Adnet, Frédéric [Auteur]
Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)]
Gueugniaud, Pierre Yves [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Tazarourte, Karim [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Mebazaa, Alexandre [Auteur]
Marqueurs cardiovasculaires en situation de stress [MASCOT (UMR_S_942 / U942)]
Fraticell, Laurie [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
El Khoury, Carlos [Auteur]
Health Service and Performance Research [HESPER]
Gueugniaud [Auteur]

Titre de la revue :

Journal of Emergency Medicine

Nom court de la revue :

J Emerg Med

Date de publication :

2020-08-08

ISSN :

0736-4679

Mot(s)-clé(s) en anglais :

out-of-hospital cardiac arrest
epinephrine
resuscitation
time-dependent propensity score

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Epinephrine effectiveness and safety are still questioned. It is well known that the effect of epinephrine varies depending on patients’ rhythm and time to injection. Objective We aimed to assess the association ...
Lire la suite >Background Epinephrine effectiveness and safety are still questioned. It is well known that the effect of epinephrine varies depending on patients’ rhythm and time to injection. Objective We aimed to assess the association between epinephrine use during out-of-hospital cardiac arrest (OHCA) care and patient 30-day (D30) survival. Methods Between 2011 and 2017, 27,008 OHCA patients were included from the French OHCA registry. We adjusted populations using a time-dependent propensity score matching. Analyses were stratified according to patient's first rhythm. After matching, 2837 pairs of patients with a shockable rhythm were created and 20,950 with a nonshockable rhythm. Results Whatever the patient's rhythm (shockable or nonshockable), epinephrine use was associated with less D30 survival (odds ratio [OR] 0.508; 95% confidence interval [CI] 0.440–0.586] and OR 0.645; 95% CI 0.549–0.759, respectively). In shockable rhythms, on all outcomes, epinephrine use was deleterious. In nonshockable rhythms, no difference was observed regarding return of spontaneous circulation and survival at hospital admission. However, epinephrine use was associated with worse neurological prognosis (OR 0.646; 95% CI 0.549–0.759). Conclusions In shockable and nonshockable rhythms, epinephrine does not seem to have any benefit on D30 survival. These results underscore the need to perform further studies to define the optimal conditions for using epinephrine in patients with OHCA.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2023-11-15T08:25:12Z
2023-12-21T10:08:14Z